Acetyl-CoA Carboxylase beta antibody (Internal Region)

Catalog No. ABIN1105210

Product Details anti-Acetyl-CoA Carboxylase beta Antibody

Target: Acetyl-CoA Carboxylase beta (ACACB)

Binding Specificity: Internal Region

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This Acetyl-CoA Carboxylase beta antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Sequence: C-QLGEPDLSDK DRKD

Specificity: This antibody recognizes ACACB

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity Chromatography

Immunogen: Synthetic Peptide (C-QLGEPDLSDKDRKD) from the internal region of Human ACACB (NP_001084.2). Genename: ACACB

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Acetyl-CoA Carboxylase beta

Target: Acetyl-CoA Carboxylase beta (ACACB)

Alternative Name: Acetyl-CoA Carboxylase 2 (ACACB Products)

Synonyms: F15C21.2 antibody, F15C21_2 antibody, acetyl-CoA carboxylase 2 antibody, ACC2 antibody, ACCB antibody, HACC275 antibody, Acc2 antibody, AI597064 antibody, AW743042 antibody, Accb antibody, acetyl-CoA carboxylase 2 antibody, acetyl-CoA carboxylase beta antibody, acetyl-Coenzyme A carboxylase beta antibody, ACC2 antibody, ACACB antibody, Acacb antibody

Background: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACC alpha (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACC beta (ACC2) is thought to control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. ACC beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. The gene encoding ACC beta maps to human chromosome 12 and encodes a mitochondiral protein expressed in heart and skeletal muscle. The catalytic core of ACC beta is homologous to that of ACC alpha, except for an additional peptide of about 150 amino acids at the N-terminusSynonyms: ACACB, ACC2, ACCB

Gene ID: 32

NCBI Accession: NP_001084

Pathways: AMPK Signaling, Ribonucleoside Biosynthetic Process