B-Cell CLL/lymphoma 2 (BCL2) (AA 41-54) antibody

Details for Product No. ABIN1105504
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Antigen
Synonyms AW986256, Bcl-2, C430015F12Rik, D630044D05Rik, D830018M01Rik, PPP1R50, BCL-2, bcl-2, Bcl2
Epitope
AA 41-54
(50), (44), (36), (28), (25), (22), (20), (13), (12), (9), (8), (8), (6), (6), (6), (6), (5), (5), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(439), (158), (124), (54), (36), (36), (14), (12), (4), (2), (2)
Host
Mouse
(367), (118), (8), (7), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(22), (17), (14), (12), (9), (7), (7), (7), (7), (7), (7), (7), (7), (6), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(329), (177), (139), (117), (89), (83), (70), (55), (55), (42), (24), (5), (2), (2), (2), (2), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN1105504
308.00 $
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Immunogen Synthetic peptide corresponding to residues 41-54pf the bcl-2 protein, conjugated to thyroglobulin.
Clone BL-2
Isotype IgG1
Specificity This antibody reacts to BCL2.
Purification Affinity chromatography
Alternative Name Bcl-2
Background Immunoreactive BCL2 protein in the neoplastic cells of almost all follicular lymphomas whereas no BCL2 protein was detected in follicles affected by nonneoplastic processes or in normal lymphoid tissue. Every tumor with molecular-genetic evidence of t(14,18) translocation expressed detectable levels of BCL2 protein, regardless of whether the breakpoint was located in or at a distance from the BCL2 gene. Overexpression of BCL2 blocks the apoptotic death of a pro-B-lymphocyte cell line.
Alternate names: Apoptosis regulator Bcl-2, B-Cell CLL/lymphoma 2, BCL2, Bcl-2 alpha
Gene ID 596
NCBI Accession NP_000624
UniProt P10415
Research Area Cancer, Apoptosis/Necrosis
Restrictions For Research Use only
Reconstitution Restore with 1.2% sodium acetate or neutral PBS
Concentration 0,1 mg/mL
Buffer 1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Prior to reconstitution store at -20°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 41-54) antibody anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 41-54) antibody
Background publications Hockenbery, Nuñez, Milliman et al.: "Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death." in: Nature, Vol. 348, Issue 6299, pp. 334-6, 1991 (PubMed).

Ngan, Chen-Levy, Weiss et al.: "Expression in non-Hodgkin's lymphoma of the bcl-2 protein associated with the t(14;18) chromosomal translocation." in: The New England journal of medicine, Vol. 318, Issue 25, pp. 1638-44, 1988 (PubMed).

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