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IFNA1 antibody

IFNA1 Reactivity: Mouse FACS, Func, EIA Host: Rat Monoclonal F18 unconjugated
Catalog No. ABIN1107635
  • Target See all IFNA1 Antibodies
    IFNA1 (Interferon, alpha 1 (IFNA1))
    Reactivity
    • 69
    • 13
    • 3
    • 2
    • 2
    • 1
    Mouse
    Host
    • 51
    • 21
    • 3
    Rat
    Clonality
    • 53
    • 22
    Monoclonal
    Conjugate
    • 36
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IFNA1 antibody is un-conjugated
    Application
    • 38
    • 30
    • 14
    • 14
    • 7
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Functional Studies (Func), Enzyme Immunoassay (EIA)
    Specificity
    This antibody recognises most isoforms of natural and recombinant alpha Interferon. It does not cross-react with Murine beta or gamma Interferon, nor with Human alpha Interferon. The antibody exhibits neutralizing activity of approximately 6.25 x 10e4 neutralizing units/mg.
    Cross-Reactivity (Details)
    Species reactivity (tested):Mouse.
    Purification
    Protein G
    Clone
    F18
    Isotype
    IgG1
    Top Product
    Discover our top product IFNA1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.1 mg/mL
    Buffer
    PBS, 0.1 % BSA
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 month.
    Expiry Date
    6 months
  • Target
    IFNA1 (Interferon, alpha 1 (IFNA1))
    Alternative Name
    IFNA1 / Interferon-alpha 1 (IFNA1 Products)
    Synonyms
    IFL antibody, IFN antibody, IFN-ALPHA antibody, IFN-alphaD antibody, IFNA13 antibody, IFNA@ antibody, Ifa1 antibody, IFN-ALPHA-1 antibody, IFN1@ antibody, IFNA1 antibody, IFN-alpha antibody, IFN-gamma antibody, IFNA antibody, IFNA2 antibody, IFNA6 antibody, IFN-alpha1 antibody, interferon alpha 13 antibody, interferon alpha 1 antibody, interferon, alpha 1 antibody, interferon, alpha 13 antibody, interferon antibody, interferon-alpha 1 antibody, interferon, alpha, leukocyte antibody, interferon-alpha-14 antibody, IFNA13 antibody, IFNA1 antibody, Ifna1 antibody, ifna1 antibody, IFNA3 antibody, IFN-ALPHA-14 antibody
    Background
    The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. Interferon alpha is produced primarily by plasmacytoid dendritic cells and is a potent component of the anti viral innate immune response, it modulates adaptive immunity. The classification of mammalian cytokines with antiviral activity, is well documented as being either Type I Interferon (IFNI) or Type II Interferon (IFNII). This is not the case for avian IFNs however, even though IFN was first detected in the chicken. A growing number of functional studies indicate similarities between chicken IFN and mammalian IFNI, revealing the conservation of cysteine residues and the existence of around ten closely related intron-less IFN alpha genes. Further research has shown that chIFN-alpha genes are strongly expressed following viral infection of monocyte-derived macrophage and embryo fibroblasts and that recombinant chicken IFN acts as a potent antiviral agent.Synonyms: IFN-alpha 1, IFNA13, Interferon alpha-D, LeIF D
    Gene ID
    15962
    NCBI Accession
    NP_034632
    UniProt
    P01572
    Pathways
    JAK-STAT Signaling, Hepatitis C
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