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VEGFR2 antibody (Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase)) (C-Term)

Details for Product anti-KDR Antibody No. ABIN115389, Supplier: Log in to see
Antigen
  • 6130401C07
  • CD309
  • fk52c05
  • flk
  • FLK-1
  • flk-1
  • Flk-1
  • FLK/KDR
  • Flk1
  • flk1
  • FLK1
  • flk1b
  • kdr
  • KDR
  • kdra
  • kdrb
  • Krd-1
  • Ly73
  • si:busm1-205d10.1
  • si:ch211-254j6.1
  • si:ch211-278f21.4
  • sVEGFR-2
  • VEGFR
  • Vegfr-2
  • vegfr-2
  • VEGFR-2
  • VEGFR2
  • vegfr2
  • vegfr4
  • vegr2
  • wu:fc31a09
  • wu:fk52c05
Alternatives
anti-Human VEGFR2 antibody for Immunohistochemistry (Frozen Sections)
Epitope
C-Term
78
53
51
37
24
24
20
18
18
17
17
15
14
14
13
12
12
10
9
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6
6
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5
5
4
4
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
555
290
153
19
5
4
3
2
2
2
1
1
1
1
1
1
1
1
1
Host
Rabbit
488
120
49
4
2
2
1
Clonality
Polyclonal
Conjugate
This VEGFR2 antibody is un-conjugated
38
27
22
15
14
12
9
7
6
5
4
4
3
3
3
3
3
3
3
3
3
3
2
2
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
409
233
205
152
105
78
34
27
24
23
17
16
8
8
7
6
5
2
2
1
1
1
1
1
Supplier
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Immunogen A synthetic peptide derived from the C-terminus of the precursor form of the Human Flk-1
Specificity This antibody reacts with a 180 kDa protein, known as Flk-1/KDR/Vascular endothelial growth factor receptor 2.
Cellular Localization:Cytoplasmic.
Purification Purified
Alternative Name CD309 / VEGFR-2 / Flk-1 (KDR Antibody Abstract)
Background CD309 is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration and differentiation. Like other growth factor receptors, upon ligand binding VEGF receptor 2 dimerises and is autophosphorylated on multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or serve as binding sites for SH2 and phosphotyrosine binding containing signalling proteins. Phosphorylation of Tyrosines 1054 and 1059 in the activation loop is required for activation of VEGF receptor 2 and its intrinsic tyrosine kinase activity. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.Synonyms: FLK1, KDR, Kinase NYK, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, VEGF Receptor 2, VEGFR2, Vascular endothelial growth factor receptor 2
Gene ID 3791
NCBI Accession NP_002244
UniProt P35968
Research Area Cytokines, Receptors
Pathways RTK Signaling
Application Notes Western Blotting. Immunohistochemistry on Paraffin Sections: Use a 1/50-1/100 dilution in an ABC method(incubation time: 30 minutes at room temperature). Formalin fixed paraffin embedded tissue sections require high temperature antigenunmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Recommended positive control: Angiosarcoma.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunohistochemistry (IHC) image for anti-VEGFR2 antibody (Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase)) (C-Term) (ABIN115389) Formalin fixed paraffin embedded human angiosarcoma stained with Flk-1 antibody
Background publications Ergün, Kiliç, Fiedler, Mukhopadhyay: "Vascular endothelial growth factor and its receptors in normal human testicular tissue." in: Molecular and cellular endocrinology, Vol. 131, Issue 1, pp. 9-20, 1997 (PubMed).

Quinn, Peters, De Vries, Ferrara, Williams: "Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 16, pp. 7533-7, 1993 (PubMed).