CD46 antibody
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- Target See all CD46 Antibodies
- CD46
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Reactivity
- Human, Cow
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This CD46 antibody is un-conjugated
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Application
- Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)
- Cross-Reactivity (Details)
- Species reactivity (tested):Human, Bovine.
- Purification
- Affinity Chromatography on Protein A
- Immunogen
- HPB-ALL human T cell line
- Clone
- MEM-258
- Isotype
- IgG1
- Top Product
- Discover our top product CD46 Primary Antibody
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- Application Notes
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Western blotting (non-reducing conditions). Immunoprecipitation. Flow cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Tris buffered saline (TBS) pH ~8.0, 15 mM Sodium Azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the original vial at 2-8 °C. Freeze stock solution or aliquots thereof at -20 °C.
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- Target
- CD46
- Alternative Name
- CD46 / MCP (CD46 Products)
- Synonyms
- AHUS2 antibody, MCP antibody, MIC10 antibody, TLX antibody, TRA2.10 antibody, Mcp antibody, CD46 antibody, CD46 molecule antibody, CD46 antigen, complement regulatory protein antibody, CD46 molecule, complement regulatory protein antibody, membrane cofactor protein-like antibody, CD46 antibody, Cd46 antibody, LOC100341359 antibody, LOC103789310 antibody
- Background
- CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.Synonyms: MIC10, Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen
- Gene ID
- 9606
- UniProt
- P15529
- Pathways
- Regulation of Actin Filament Polymerization
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