4F2 antibody, 4F2HC antibody, 4T2HC antibody, CD98 antibody, CD98HC antibody, MDU1 antibody, NACAE antibody, Mdu1 antibody, MGC53951 antibody, slc3a2 antibody, MGC53965 antibody, SLC3A2 antibody, AI314110 antibody, Cd98 antibody, Ly-10 antibody, Ly-m10 antibody, Ly10 antibody, Mgp-2hc antibody, fc65h12 antibody, wu:fc65h12 antibody, id:ibd1327 antibody, sb:cb519 antibody, wu:fe14a07 antibody, wu:fq18d12 antibody, zgc:55813 antibody, solute carrier family 3 member 2 antibody, solute carrier family 3 (amino acid transporter heavy chain), member 2 L homeolog antibody, solute carrier family 3 (amino acid transporter heavy chain), member 2 S homeolog antibody, solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 antibody, solute carrier family 3 (amino acid transporter heavy chain), member 2a antibody, solute carrier family 3 (amino acid transporter heavy chain), member 2b antibody, SLC3A2 antibody, Slc3a2 antibody, slc3a2.L antibody, slc3a2.S antibody, slc3a2a antibody, slc3a2b antibody
Background
CD98, also known as 4F2, FRP-1, or RL-388, is the heavy subunit of the cell-surface protein complex that induces the uptake of dibasic and neutral amino acids. CD98 heavy chain (CD98hc) is an 80-85 kDa, type II membrane glycoprotein that is disulfide-linked to one of several non-glycosylated 40-45 kDa light chains (LAT1, the integrin a 3 subunit, or one of several members of the glycoprotein-associat ed amino acid transporter family). The CD98 complex is a multi-functional protein that plays a role in the regulation of virus-mediated cell fusion, oncogenesis, amino acid transport, integrin regulation, and Na + -Ca 2+ exchange. It is widely expressed on the surface of activated lymphocytes and various tumor cells.Synonyms: 4F2 cell-surface antigen heavy chain, 4F2 heavy chain antigen, 4F2hc, Lymphocyte activation antigen 4F2 large subunit, MDU1