FLT3 antibody (N-Term)
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- Target See all FLT3 Antibodies
- FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This FLT3 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF)
- Specificity
- At least three isoforms of FLT3 are known to exist, this antibody will detect all isoforms.
- Purification
- Affinity chromatography purified via peptide column
- Immunogen
- FLT3 antibody was raised against an 18 amino acid synthetic peptide near the center of human FLT3.
- Isotype
- IgG
- Top Product
- Discover our top product FLT3 Primary Antibody
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- Application Notes
- FLT3 antibody can be used for detection of FLT3 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
- Comment
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(NT) Fms-like tyrosine kinase 3
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS containing 0.02 % Sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Storage
- 4 °C
- Storage Comment
- FLT3 antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.
- Expiry Date
- 12 months
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- Target
- FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
- Alternative Name
- FLT3 (FLT3 Products)
- Synonyms
- FLT3 antibody, B230315G04 antibody, CD135 antibody, Flk-2 antibody, Flk2 antibody, Flt-3 antibody, Ly72 antibody, wmfl antibody, FLK-2 antibody, FLK2 antibody, STK1 antibody, fms related tyrosine kinase 3 antibody, FMS-like tyrosine kinase 3 antibody, fms-related tyrosine kinase 3 antibody, FLT3 antibody, Flt3 antibody
- Background
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FLT3 is a member of the class III receptor tyrosine kinase family and its internal tandem duplication (ITD) is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. It is a membrane bound glycosylated protein that is expressed primarily in early hematopoietic progenitor cells. Upon binding its ligand FL, FLT3 activates multiple signaling pathways including the PI3K/Akt and Ras/MEK/MAPK pathways. In cells expressing FLT3-ITD, these pathways are constitutively on, resulting in abnormal cell growth and anti-apoptotic activity.
Synonyms: Fms-like tyrosine kinase 3, receptor-type tyrosine-protein kinase FLT3, CD135, FL cytokine receptor, fetal liver kinase 2, stem cell tyrosine kinase 1 - Molecular Weight
- 109 kDa
- Gene ID
- 2322
- NCBI Accession
- NP_004110
- Pathways
- RTK Signaling
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