Sirtuin 5 (SIRT5) (Middle Region) antibody

Details for Product No. ABIN182560
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Antigen
Synonyms SIRT5, sir2l5, zgc:92288, SIR2L5, sirt5-a, 0610012J09Rik, 1500032M05Rik, AV001953
Epitope
Middle Region
(23), (7), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Pig (Porcine), Human
(89), (34), (26), (3), (3), (2), (2), (1), (1)
Host
Rabbit
(67), (23), (8), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(8), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(85), (38), (20), (17), (16), (12), (10), (7), (4), (3)
Pubmed 1 reference available
Quantity 100 µg
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Catalog No. ABIN182560
229.00 $
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Immunogen Synthetic peptide directed towards the middle region of human SIRT5
Sequence LSGKGAPEPG TQDASIPVEK LPRCEEAGCG GLLRPHVVWF GENLDPAILE
Predicted Reactivity Human : 100 %, Pig : 80 %, Mouse : 70 %
Characteristics This is a rabbit polyclonal antibody against SIRT5. It was validated on Western Blot and immunohistochemistry.
Purification Protein A purified
Alternative Name SIRT5
Background SIRT5 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family.
Molecular Weight 33 kDa
Gene ID 23408
NCBI Accession NP_112534, NM_031244
UniProt Q9NXA8
Research Area Chromatin and Nuclear Signaling, Proteases
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 299 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Sirtuin 5 (SIRT5) (Middle Region) antibody WB Suggested Anti-SIRT5 Antibody Titration: 1.0-2.0ug/ml
Positive Control: Jurkat cell lysate
anti-Sirtuin 5 (SIRT5) (Middle Region) antibody (2) anti-Sirtuin 5 (SIRT5) (Middle Region) antibody (Image 2)
anti-Sirtuin 5 (SIRT5) (Middle Region) antibody (3) anti-Sirtuin 5 (SIRT5) (Middle Region) antibody (Image 3)
Background publications Frye: "Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins." in: Biochemical and biophysical research communications, Vol. 273, Issue 2, pp. 793-8, 2000 (PubMed).

Validation Images
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