Chromobox Homolog 3 (CBX3) (Middle Region) antibody

Details for Product No. ABIN183071
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Antigen
Synonyms HP1g, M32, HECH, HP1-GAMMA, HP1Hs-gamma, cbx3, cbx3a, xhp1g, Hp1-gamma
Epitope
Middle Region
(13), (11), (8), (5), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine), Xenopus laevis, Human, Chicken
(74), (58), (50), (21), (15), (15), (3), (2)
Host
Rabbit
(61), (10), (8), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(57), (34), (20), (20), (19), (13), (8), (5), (4), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN183071
289.00 $
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Immunogen Synthetic peptide directed towards the middle region of human CBX3
Sequence WEPEENLDCP ELIEAFLNSQ KAGKEKDGTK RKSLSDSESD DSKSKKKRDA
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Rat : 100 %, Pig : 90 %, Chicken : 80 %, African clawed frog : 80 %
Characteristics This is a rabbit polyclonal antibody against CBX3. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name CBX3
Background At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. CBX3 binds DNA and is a component of heterochromatin. CBX3 also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of CBX3 may explain the association of heterochromatin with the inner nuclear membrane.At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
Molecular Weight 21 kDa
Gene ID 11335
NCBI Accession NP_009207, NM_007276
UniProt Q13185
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 183 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Chromobox Homolog 3 (CBX3) (Middle Region) antibody WB Suggested Anti-CBX3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:12500
Positive Control: Jurkat cell lysate
anti-Chromobox Homolog 3 (CBX3) (Middle Region) antibody (2) WB Suggested Anti-CBX3
Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:12500
Positive Control: Jurkat cell lysate
CBX3 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells
Background publications Scherer, Cheung, MacDonald et al.: "Human chromosome 7: DNA sequence and biology." in: Science (New York, N.Y.), Vol. 300, Issue 5620, pp. 767-72, 2003 (PubMed).

Validation Images
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