JUP antibody

Catalog No. ABIN187369

Product Details anti-JUP Antibody

Target: JUP (Junction Plakoglobin (JUP))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This JUP antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Specificity: Reacts with human plakoglobin. Cross-reacts with rat and weakly cross-reacts with mouse plakoglobin. Species Reactivity: Human, mouse and rat. Others not tested.

Sterility: 0.2 μm filtered

Clone: 15F11

Isotype: IgG1

Application Details

Application Notes: Immunofluorescence: (cells fixed in paraformaldehyde) Use at a 1:10 dilution Immunoprecipitation Western blot: Use at a 1:10 dilution The optimal dilution for a specific application should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 1 mL at 100 µg/mL of 0.2 µm filtered antibody solution in PBS containing 0.1% protein stabilizer.

Storage: 4 °C

Target Details for JUP

Target: JUP (Junction Plakoglobin (JUP))

Alternative Name: Junction plakoglobin (JUP Products)

Synonyms: ARVD12 antibody, CTNNG antibody, DP3 antibody, DPIII antibody, PDGB antibody, PKGB antibody, arvd12 antibody, ctnng antibody, dp3 antibody, dpiii antibody, pdgb antibody, pkgb antibody, plak antibody, D930025P04Rik antibody, PG antibody, cb80 antibody, danPG antibody, fb11b06 antibody, jup antibody, wu:fb11b06 antibody, junction plakoglobin antibody, junction plakoglobin L homeolog antibody, Junction plakoglobin antibody, junction plakoglobin a antibody, junction plakoglobin S homeolog antibody, JUP antibody, Jup antibody, jup antibody, jup.L antibody, Tsp_06656 antibody, plak antibody, jupa antibody, jup.S antibody

Background: Plakoglobin belongs together with alpha- and beta-catenin to the catenin family. Catenins mediate cell-cell adhesion by interaction with cadherins. Plakoglobin is found in desmosomes and adherens junctions. Plakoglobin is highly homologous to beta-catenin although its function differs from that of beta-catenin. Whereas beta-catenin has been found in potentiating hyperproliferation and tumor formation, plakoglobin can suppress tumorigenicity. Overexpression of plakoglobin has been shown to suppress cell proliferation and cell tumorigenicity in animals. Furthermore reduced plakoblobin expression has been found in tumor tissues and metastatic lesions of renal cells, esophageal carcinomas and in skin carcinomas.

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location