Caspase 9 antibody (N-Term)

Catalog No. ABIN187521

Product Details anti-Caspase 9 Antibody

Target: Caspase 9 (CASP9) (Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9))

Binding Specificity: N-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Caspase 9 antibody is un-conjugated

Application: Western Blotting (WB)

Sterility: 0.2 μm filtered

Immunogen: Synthetic peptide corresponding to amino acids 2 to 22 of human caspase-9.

Clone: LAP6-96

Isotype: IgG1

Application Details

Application Notes: Western Blot The optimal dilution for a specific application should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Mouse monoclonal antibody against human Caspase-9 (cysteine-requiring aspartate protease-9). Available in 100 µl vials at a concentration of 1 mg/ml (100 µg) in PBS with 0.08% sodium azide. Purified by 0.2 µm sterile filtration.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for Caspase 9

Target: Caspase 9 (CASP9) (Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9))

Alternative Name: Caspase-9 (CASP9 Products)

Synonyms: CASP9 antibody, AI115399 antibody, APAF-3 antibody, AW493809 antibody, CASP-9 antibody, Caspase-9 antibody, ICE-LAP6 antibody, Mch6 antibody, Apaf3 antibody, Casp-9-CTD antibody, Casp9_v1 antibody, Ice-Lap6 antibody, APAF3 antibody, MCH6 antibody, PPP1R56 antibody, caspase 9 antibody, CASP9 antibody, Casp9 antibody

Background: Caspases are key effectors of programmed cell death. They are synthesized as inactive pro-enzymes, which are activated by cleavage at a specific aspartate residue to form two subunits. These subunits are normally linked together by a linker, which may be involved in the regulation of the different caspases. Caspase-9 is a member of the CED-3 family and is very similar to caspase-3. Pro-caspase-9 can be activated by either caspase-3 or granzyme B, although they cleave the pro-enzyme to different size subunits. Cleavage by granzyme B produces an active enzyme, which is capable of cleaving PARP. Also, the ability of caspase-3 to activate caspase-9 seems to suggest that caspase-9 is further downstream of caspase-3 and may be involved in later changes in cells observed undergoing apoptosis.

Pathways: MAPK Signaling, RTK Signaling, Apoptosis, Caspase Cascade in Apoptosis, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Endopeptidase Activity