This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This ATP2A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 974-1001 amino acids from the C-terminal region of human ATP2A1.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Salanova, Schiffl, Blottner: "Atypical fast SERCA1a protein expression in slow myofibers and differential S-nitrosylation prevented by exercise during long term bed rest." in: Histochemistry and cell biology, Vol. 132, Issue 4, pp. 383-94, (2009) (PubMed).
Chami, Oulès, Szabadkai, Tacine, Rizzuto, Paterlini-Bréchot: "Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress." in: Molecular cell, Vol. 32, Issue 5, pp. 641-51, (2008) (PubMed).
Thorleifsson, Walters, Gudbjartsson, Steinthorsdottir, Sulem, Helgadottir, Styrkarsdottir, Gretarsdottir, Thorlacius, Jonsdottir, Jonsdottir, Olafsdottir, Olafsdottir, Jonsson, Jonsson et al.: "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity...." in: Nature genetics, Vol. 41, Issue 1, pp. 18-24, (2008) (PubMed).
ATP2A1 encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction.