This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This AP2 alpha antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-133 amino acids from the N-terminal region of human AP2 alpha.
TFAP2A
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Application Notes
WB: 1:1000
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Semenza: "Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1." in: The Biochemical journal, Vol. 405, Issue 1, pp. 1-9, (2007) (PubMed).
Provenzano, Yu, Hitchler, Fitzgerald, Robinson, Wayne, Ver Meer, Domann: "AP-2 participates in the transcriptional control of the amyloid precursor protein (APP) gene in oral squamous cell carcinoma." in: Experimental and molecular pathology, Vol. 83, Issue 2, pp. 277-82, (2007) (PubMed).
Han, Ritzenthaler, Wingerd, Rivera, Roman: "Extracellular matrix fibronectin increases prostaglandin E2 receptor subtype EP4 in lung carcinoma cells through multiple signaling pathways: the role of AP-2." in: The Journal of biological chemistry, Vol. 282, Issue 11, pp. 7961-72, (2007) (PubMed).
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2 alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle.