SIGIRR antibody (C-Term)

Catalog No. ABIN1887448

Product Details anti-SIGIRR Antibody

Target: SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIGIRR antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), ELISA

Purification: Affinity chromatography purified via peptide column

Immunogen: Synthetic peptide corresponding to 15 amino acids at the C-terminus of mouse SIGIRR.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for SIGIRR

Target: SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))

Alternative Name: SIGIRR (SIGIRR Products)

Synonyms: TIR8 antibody, AI256711 antibody, sc:d148 antibody, RGD1306732 antibody, single Ig and TIR domain containing antibody, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain antibody, SIGIRR antibody, Sigirr antibody, sigirr antibody

Background: SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily.Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain.The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses.SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family.Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling.However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R.It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion.

Pathways: Toll-Like Receptors Cascades