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Retinoblastoma 1 antibody (RB1) (Ser795)

Details for Product anti-RB1 Antibody No. ABIN197281, Supplier: Log in to see
Antigen
Alternatives
anti-Human Retinoblastoma 1 antibody for Immunohistochemistry (Frozen Sections)
Epitope
Ser795
51
50
48
39
35
28
25
20
17
16
16
13
9
8
8
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7
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3
3
3
2
2
2
2
2
1
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1
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1
1
1
1
1
1
1
1
1
1
1
1
1
1
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Reactivity
Human, Mouse (Murine), Rat (Rattus)
490
252
228
11
8
5
5
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4
3
3
2
2
Host
Rabbit
437
56
2
Clonality
Polyclonal
Conjugate
This Retinoblastoma 1 antibody is un-conjugated
22
20
20
15
13
13
10
9
9
7
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7
Application
Western Blotting (WB)
285
209
170
83
66
60
45
20
10
8
7
6
5
5
2
2
2
1
1
Supplier
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Immunogen Synthesized non-phosphopeptide derived from human Rb around the phosphorylation site of serine 795
Sequence P-S-SP-P-L
Specificity This detects endogenous levels of total Rb protein.
Purification Affinity-chromatography using epitope-specific immunogen
Alternative Name Retinoblastoma-Associated Protein / RB1 (RB1 Antibody Abstract)
Background Synonyms: OSRC, Rb, Retinoblastoma 1, p105-Rb, pRb, pp110
Gene ID 5925
NCBI Accession NP_000312
UniProt P06400
Pathways Cell Division Cycle
Application Notes Western blot (1: 500-1: 1000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Supplier Images
 image for anti-Retinoblastoma 1 antibody (RB1) (Ser795) (ABIN197281) anti-Retinoblastoma 1 (RB1) (Ser795) antibody
Background publications Roesch, Becker, Meyer et al.: "Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 18, Issue 4, pp. 565-72, 2005 (PubMed).

Chadee, Kyriakis: "MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation." in: Nature cell biology, Vol. 6, Issue 8, pp. 770-6, 2004 (PubMed).

Knudsen, Wang: "Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation." in: Molecular and cellular biology, Vol. 17, Issue 10, pp. 5771-83, 1997 (PubMed).

Knudsen, Wang: "Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites." in: The Journal of biological chemistry, Vol. 271, Issue 14, pp. 8313-20, 1996 (PubMed).