GZMB antibody (AA 21-247)

Catalog No. ABIN1992461

Product Details anti-GZMB Antibody

Target: GZMB (Granzyme B (GZMB))

Binding Specificity: AA 21-247

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GZMB antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Granzyme B protein (21-247AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:500-1:1000, IF:1:200-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin^TM: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for GZMB

Target: GZMB (Granzyme B (GZMB))

Alternative Name: GZMB (GZMB Products)

Synonyms: CCPI antibody, CGL-1 antibody, CGL1 antibody, CSP-B antibody, CSPB antibody, CTLA1 antibody, CTSGL1 antibody, HLP antibody, SECT antibody, granzyme B antibody, GZMB antibody

Background:

Background: This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

Aliases: C11 antibody, Cathepsin G like 1 antibody, Cathepsin G-like 1 antibody, CCPI antibody, CGL 1 antibody, CGL1 antibody, CSP B antibody, CSPB antibody, CTLA 1 antibody, CTLA-1 antibody, CTLA1 antibody, CTSGL1 antibody, Cytotoxic serine protease B antibody, Cytotoxic T lymphocyte associated serine esterase 1 antibody, Cytotoxic T lymphocyte proteinase 2 antibody, Cytotoxic T-lymphocyte proteinase 2 antibody, Fragmentin 2 antibody, Fragmentin-2 antibody, GRAB_HUMAN antibody, Granzyme 2 antibody, Granzyme B (granzyme 2, cytotoxic T lymphocyte associated serine esterase 1) antibody, Granzyme B antibody, Granzyme-2 antibody, GranzymeB antibody, GRB antibody, Gzmb antibody, Hlp antibody, Human lymphocyte protein antibody, Lymphocyte protease antibody, Protease, serine, B antibody, SECT antibody, T cell serine protease 1 3E antibody, T cell serine protease 1-3E antibody, T-cell serine protease 1-3E antibody

UniProt: P10144

Pathways: Apoptosis, Caspase Cascade in Apoptosis