SOCS1 antibody (AA 1-211) (HRP)

Catalog No. ABIN1994214

Product Details anti-SOCS1 Antibody (HRP)

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Binding Specificity: AA 1-211

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS1 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Suppressor of cytokine signaling 1 protein (1-211AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin^TM: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze.
Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SOCS1

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Alternative Name: SOCS1 (SOCS1 Products)

Synonyms: socs1 antibody, zgc:91868 antibody, jab antibody, cis1 antibody, ssi1 antibody, tip3 antibody, cish1 antibody, ssi-1 antibody, socs-1 antibody, SOCS1 antibody, LOC100228306 antibody, socs1b antibody, CIS1 antibody, CISH1 antibody, JAB antibody, SOCS-1 antibody, SSI-1 antibody, SSI1 antibody, TIP3 antibody, Cish1 antibody, Cish7 antibody, Socs-1 antibody, suppressor of cytokine signaling 1a antibody, suppressor of cytokine signaling 1 antibody, suppressor of cytokine signaling 1 L homeolog antibody, socs1a antibody, socs1 antibody, SOCS1 antibody, socs1.L antibody, Socs1 antibody

Background:

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival By similarity. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

Aliases: CISH 1 antibody, CISH1 antibody, Cytokine inducible SH2 protein 1 antibody, JAB antibody, JAK binding protein antibody, JAK-binding protein antibody, Janus kinase binding protein antibody, SOCS 1 antibody, SOCS-1 antibody, Socs1 antibody, SOCS1_HUMAN antibody, SSI 1 antibody, SSI-1 antibody, SSI1 antibody, STAT induced STAT inhibitor 1 antibody, STAT-induced STAT inhibitor 1 antibody, Suppressor of cytokine signaling 1 antibody, Supressor of cytokine signalling 1 antibody, TEC interacting protein 3 antibody, Tec-interacting protein 3 antibody, TIP 3 antibody, TIP-3 antibody, TIP3 antibody

UniProt: O15524

Pathways: JAK-STAT Signaling, Interferon-gamma Pathway, TLR Signaling, Response to Growth Hormone Stimulus