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CHEK1 antibody (Middle Region)
CHEK1
Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-CHEK1 Antibody
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Target
See all CHEK1 Antibodies
CHEK1
(Checkpoint Kinase 1 (CHEK1))
Binding Specificity
All epitopes for CHEK1 antibodies
Middle Region
Reactivity
All reactivities for CHEK1 antibodies
Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig
Host
All hosts for CHEK1 antibodies
Rabbit
Clonality
All clonalities for CHEK1 antibodies
Polyclonal
Conjugate
All conjugates for CHEK1 antibodies
This CHEK1 antibody is un-conjugated
Application
All applications for CHEK1 antibodies
Western Blotting (WB)
Sequence
NLDF SPVNSASSEE NVKYSSSQPE PRTGLSLWDT SPSYIDKLVQ GISFS
Predicted Reactivity
Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 100%
Characteristics
This is a rabbit polyclonal antibody against CHEK1. It was validated on Western Blot.
Purification
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human CHEK1
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Alternatives
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Application Details
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Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeat freeze-thaw cycles.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for CHEK1
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Target
CHEK1
(Checkpoint Kinase 1 (CHEK1))
Alternative Name
CHEK1 (CHEK1 Products )
Synonyms
An08g10320 antibody, AO090003000441 antibody, CHK1 antibody, chk1 antibody, C85740 antibody, Chk1 antibody, rad27 antibody, id:ibd2720 antibody, zgc:56093 antibody, CHEK1 antibody, checkpoint kinase 1 antibody, serine/threonine-protein kinase chk1 antibody, serine/threonine-protein kinase Chk1 antibody, CAMK/CAMKL/CHK1 protein kinase Chk1 antibody, checkpoint kinase 1 S homeolog antibody, CHEK1 antibody, ANI_1_2436074 antibody, AOR_1_768154 antibody, PTRG_04183 antibody, SJAG_01680 antibody, PAAG_04978 antibody, MCYG_03290 antibody, VDBG_03742 antibody, chek1.S antibody, Chek1 antibody, chek1 antibody
Background
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. Alias Symbols: CHK1 Protein Size: 432
Molecular Weight
47 kDa
Gene ID
1111
NCBI Accession
NM_001114121 , NP_001107593
UniProt
O14757
Pathways
p53 Signaling , Apoptosis , Cell Division Cycle , DNA Damage Repair
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