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ERCC1 antibody (N-Term)
ERCC1
Reactivity: Human, Mouse, Rat, Dog, Rabbit, Guinea Pig
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-ERCC1 Antibody
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Target
See all ERCC1 Antibodies
ERCC1
(Excision Repair Cross Complementing Polypeptide-1 (ERCC1))
Binding Specificity
All epitopes for ERCC1 antibodies
N-Term
Reactivity
All reactivities for ERCC1 antibodies
Human, Mouse, Rat, Dog, Rabbit, Guinea Pig
Host
All hosts for ERCC1 antibodies
Rabbit
Clonality
All clonalities for ERCC1 antibodies
Polyclonal
Conjugate
All conjugates for ERCC1 antibodies
This ERCC1 antibody is un-conjugated
Application
All applications for ERCC1 antibodies
Western Blotting (WB)
Sequence
TVDTSAQAAP QTYAEYAISQ PLEGAGATCP TGSEPLAGET PNQALKPGAK
Predicted Reactivity
Dog: 86%, Guinea Pig: 79%, Human: 100%, Mouse: 85%, Rabbit: 79%, Rat: 79%
Characteristics
This is a rabbit polyclonal antibody against ERCC1. It was validated on Western Blot.
Purification
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the N-terminal region of human ERCC1
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Application Details
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Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeat freeze-thaw cycles.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for ERCC1
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Target
ERCC1
(Excision Repair Cross Complementing Polypeptide-1 (ERCC1))
Alternative Name
ERCC1 (ERCC1 Products )
Synonyms
COFS4 antibody, RAD10 antibody, UV20 antibody, Ercc-1 antibody, ercc1 antibody, T12H1.18 antibody, T12H1_18 antibody, UV REPAIR DEFICIENT 7 antibody, UVR7 antibody, ERCC excision repair 1, endonuclease non-catalytic subunit antibody, excision repair cross-complementing rodent repair deficiency, complementation group 1 antibody, DNA excision repair protein ERCC-1 antibody, nucleotide repair protein antibody, excision repair cross-complementation group 1 L homeolog antibody, excision repair cross-complementation group 1 antibody, ERCC1 antibody, Ercc1 antibody, CC1G_04546 antibody, CpipJ_CPIJ013903 antibody, PITG_13719 antibody, ercc1 antibody, ercc1.L antibody
Background
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. Alias Symbols: UV20, COFS4, RAD10 Protein Size: 213
Molecular Weight
23 kDa
Gene ID
2067
NCBI Accession
NM_001166049 , NP_001159521
UniProt
P07992
Pathways
DNA Damage Repair , Production of Molecular Mediator of Immune Response
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