KCNQ2
Reactivity: Rat, Human, Mouse
WB, IHC, IF
Host: Guinea Pig
Polyclonal
unconjugated
Application Notes
KCNQ2 antibody can be used for detection of KCNQ2 by ELISA at 1:12500. KCNQ2 antibody can be used for detection of KCNQ2 by western blot at 1.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
Concentration
1 mg/mL
Buffer
Antibody is lyophilized in PBS buffer with 2 % sucrose.
Handling Advice
As with any antibody avoid repeat freeze-thaw cycles.
Storage
4 °C/-20 °C
Storage Comment
For short periods of storage (days) store at 4 °C. For longer periods of storage, store KCNQ2 antibody at -20 °C.
Target
KCNQ2
(Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2))
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by KCNQ2 and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1).