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TNF alpha antibody (PE)
TNF alpha
Reactivity: Human
FACS
Host: Mouse
Monoclonal
MAb11
PE
Product Details anti-TNF alpha Antibody (PE)
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Target
See all TNF alpha Antibodies
TNF alpha
(Tumor Necrosis Factor alpha (TNF alpha))
Reactivity
All reactivities for TNF alpha antibodies
Human
Host
All hosts for TNF alpha antibodies
Mouse
Clonality
All clonalities for TNF alpha antibodies
Monoclonal
Conjugate
All conjugates for TNF alpha antibodies
This TNF alpha antibody is conjugated to PE
Application
All applications for TNF alpha antibodies
Flow Cytometry (FACS)
Specificity
The MAb11 monoclonal antibody specifically reacts with human tumor necrosis factor alpha (TNF-alpha), a 157 amino acid non-glycosylated protein.
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clone
MAb11
Isotype
IgG1 kappa
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
0.5 mg/mL
Buffer
Phosphate-buffered aqueous solution, ≤0.09 % Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Storage
4 °C
Storage Comment
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Target Details for TNF alpha
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Target
TNF alpha
(Tumor Necrosis Factor alpha (TNF alpha))
Alternative Name
TNF-alpha (TNF alpha Products )
Synonyms
DIF antibody, TNF-alpha antibody, TNFA antibody, TNFSF2 antibody, RATTNF antibody, Tnfa antibody, tnf antibody, TNF-a antibody, TNFalpha antibody, Tnfsf1a antibody, TNFa antibody, cTNF antibody, Tnf-alpha antibody, tnfa-like antibody, TNF-ALPHA antibody, dif antibody, tnfa antibody, xtnf antibody, tnfsf2 antibody, tnf-alpha antibody, Cachectin antibody, tumor necrosis factor antibody, tumor necrosis factor b (TNF superfamily, member 2) antibody, tumor necrosis factor alpha antibody, tumor necrosis factor a (TNF superfamily, member 2) antibody, TNF antibody, Tnf antibody, tnf antibody, tnfb antibody, tnf-alpha antibody, LOC103694380 antibody, tnfa antibody
Background
The MAb11 monoclonal antibody specifically reacts with human tumor necrosis factor alpha (TNF-alpha), a 157 amino acid non-glycosylated protein. TNF-alpha is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-alpha also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. The MAB11 antibody was generated from recombinant human TNF and is reported to be a neutralizing antibody.
Gene ID
7124
UniProt
P01375
Pathways
NF-kappaB Signaling , Apoptosis , Caspase Cascade in Apoptosis , TLR Signaling , Cellular Response to Molecule of Bacterial Origin , Regulation of Leukocyte Mediated Immunity , Positive Regulation of Immune Effector Process , Production of Molecular Mediator of Immune Response , Positive Regulation of Endopeptidase Activity , Hepatitis C , Protein targeting to Nucleus , Inflammasome
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