HVEM (TNFRSF14)
(Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))
Reactivity
Mouse
Host
Armenian Hamster
Clonality
Monoclonal
Conjugate
This HVEM antibody is conjugated to APC
Application
Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)
Purification
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
Herpes Virus Entry Mediator (HVEM, TR2) is a type I transmembrane protein of TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HAS) entry. Binding of HSV viral envelope glycoprotein D to this receptor has been shown to be part of the viral entry mechanism. It is expressed on most cell types, including T cells, B cells, monocytes, neutrophils, and dendritic cells. It is also found in brain, heart, kidney, liver, and other organs. The ligands of HVEM are LIGHT, BTLA, LTα, and CD160. HVEM activates NF-kB through the TNF-related cytokine LIGHT to serve as a costimulatory pathway during T cell activation. HVEM also functions as a ligand for the Ig superfamily members B and T lymphocyte attenuator (BTLA) and CD160 to deliver a coinhibitory signal and limit inflammatory responses initiated by T cells. HVEM plays an important role in regulating lymphocyte activation and homeostasis in immune responses.