HVEM antibody

Catalog No. ABIN2664470

Product Details anti-HVEM Antibody

Target: HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HVEM antibody is un-conjugated

Application: Flow Cytometry (FACS)

Characteristics: The 122 antibody recognizes human HVEM also known as herpesvirus entry mediator A, tumor necrosis factor receptor superfamily, member 14, TNFRSF14, and tumor necrosis factor receptor like 2. HVEM, a member of the TNFR superfamily, is a type I transmembrane protein containing 2 TNF receptor domains with a predicted molecular weight of approximately 30 kD. HVEM is widely expressed in blood vessels, brain, heart, kidney, liver, lung, prostate, spleen, thymus and other organs. Resting T cells and naive and memory B cells express high levels of HVEM as well. In humans, HVEM is not expressed in germinal center B cells. Immature dendritic cells express high levels of HVEM that is downregulated upon maturation. HVEM plays an important role in herpes simplex virus pathogenesis by enhancing entry into cells. Signaling through HVEM activates JNK1, NF-κB and AP-1 to control gene expression in response to infection or cellular stress and activate the immune response. HVEM binds to LIGHT and has also been shown to associate with several other proteins including TRAF1, TRAF2, TRAF3, TRAF5, B and T lymphocyte associated protein (BTLA), and estrogen receptor alpha.

Purification: The antibody was purified by affinity chromatography.

Clone: 122

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for HVEM

Target: HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))

Alternative Name: CD270 (TNFRSF14 Products)

Synonyms: ATAR antibody, CD270 antibody, HVEA antibody, HVEM antibody, LIGHTR antibody, TR2 antibody, Atar antibody, HveA antibody, Hvem antibody, Tnfrs14 antibody, TNF receptor superfamily member 14 antibody, tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) antibody, Tnfrsf14 antibody, TNFRSF14 antibody

Target Type: Viral Protein

Pathways: Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints