TLR3 antibody

Catalog No. ABIN2664507

Product Details anti-TLR3 Antibody

Target: TLR3 (Toll-Like Receptor 3 (TLR3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TLR3 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography.

Clone: TLR-104

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for TLR3

Target: TLR3 (Toll-Like Receptor 3 (TLR3))

Alternative Name: CD283 (TLR3 Products)

Synonyms: CD283 antibody, IIAE2 antibody, AI957183 antibody, zgc:123006 antibody, toll like receptor 3 antibody, toll-like receptor 3 antibody, TLR3 antibody, Tlr3 antibody, tlr3 antibody

Background: Toll-like receptor 3 (TLR3) is a 104 kD protein also known as CD283. It is expressed selectively on the cytoplasmic membrane and intracellularly in dendritic cells. TLR3 is also highly expressed in the placenta, pancreas, heart, liver, lung, and muscle. TLR3 is a pattern recognition receptor that participates in innate immune response to microbial pathogens. The ligands recognized by TLR3 are polyinosine-polycytidylic acid (Poly(I:C)) and dsRNA. TLR3 ligands induce NF-κB activation (via TRIF-linked RIP1/TLR3 interactions) and cytokine production. TLR3 has been shown to interact with a number of proteins including MYD88, TRAF6, TRIAD3, MAP3K7, and TAB2. This antibody is useful for flow cytometry and Western blotting.

Pathways: TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades