GZMB antibody (AA 21-247)

Catalog No. ABIN2666250

Product Details anti-GZMB Antibody

Target: GZMB (Granzyme B (GZMB))

Binding Specificity: AA 21-247

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GZMB antibody is un-conjugated

Application: Biochemical Assay (BCA)

Purification: The antibody was purified by affinity chromatography.

Immunogen: AA 21-247 of Human Granzyme B produced in E. coli.

Clone: O94E6-GZMB

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Upon receipt, store undiluted at 4°C

Target Details for GZMB

Target: GZMB (Granzyme B (GZMB))

Alternative Name: Granzyme B (GZMB Products)

Synonyms: CCPI antibody, CGL-1 antibody, CGL1 antibody, CSP-B antibody, CSPB antibody, CTLA1 antibody, CTSGL1 antibody, HLP antibody, SECT antibody, granzyme B antibody, GZMB antibody

Background: Granzyme B is a serine protease that is produced mainly by cytotoxic T cells (CTL) and natural killer (NK) cells. It plays an important role in cytotoxic lymphocyte-mediated apoptosis, chronic inflammation, and impaired wound healing. Granzyme B is packaged in cytoplasmic granules that are exocytosed towards a bound target cell, which subsequently activates multiple protein substrates that induce apoptosis. Perforin facilitates the transfer of Granzyme B into the target cell. Most circulating CD56+, CD8-, NK cells, and approximately half of circulating CD8+ T cells coexpress both Granzyme A and B. The activation of CD8+ and CD4+ T lymphocytes induce substantial expression of Granzyme B, but not Granzyme A. Recently, Granzyme B has been found to be produced by other cell types such as CD34+ hematopoietic progenitor cells, keratinocytes, basophils, mast cells, plasmacytoid dendritic cells, B cells, and smooth muscle cells. Elevated levels of Granzyme B are also found in some kinds of autoimmune diseases, type 1 diabetes, and cardiovascular diseases.

Pathways: Apoptosis, Caspase Cascade in Apoptosis