IRF1 antibody
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- Target See all IRF1 Antibodies
- IRF1 (Interferon Regulatory Factor 1 (IRF1))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This IRF1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purification
- Affinity purified.
- Clone
- 13H3A44
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product IRF1 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Upon receipt, store undiluted at 4°C.
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- Target
- IRF1 (Interferon Regulatory Factor 1 (IRF1))
- Alternative Name
- IRF1 (IRF1 Products)
- Synonyms
- irf1 antibody, zgc:136945 antibody, IRF1 antibody, irf11 antibody, zgc:103566 antibody, IRF-1 antibody, MAR antibody, AU020929 antibody, Irf-1 antibody, interferon regulatory factor 1 antibody, interferon regulatory factor 1a antibody, interferon regulatory factor 1b antibody, IRF1 antibody, irf1a antibody, irf1b antibody, Irf1 antibody
- Background
- IRF1 is the first identified member of the interferon regulatory transcription factor family. Its expression is induced in response to pathogen infection or the stimulation of several cytokines, including type I and II IFN, IL-1, IL-6, and TNF-α. Upon stimulation, IRF1 is transcriptionally activated by STAT1 and NFκB transcription factors via the GAS (interferon-gamma-activated sequence) element in the IRF1 promoter. IRF1 plays important roles in mediating immune response during infection and development of T cells and NK cells. In addition to the immunomodulatory functions, IRF1 has also shown to be involved in the regulation of cell cycle progression, tumor suppression, and apoptosis. IRF1-mediated transcription can be repressed by IRF2 through competing for the same binding region on the promoters.
- Pathways
- Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Immune Effector Process, Hepatitis C, Autophagy
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