The OX-42 monoclonal antibody specifically binds to the CR3 complement (C3bi) receptor found on most monocytes, granulocytes, macrophages, dendritic cells, and microglia. It appears to recognize a common epitope shared by CD11b and CD11c (integrin αM and αX chains). OX-42 antibody inhibits C3bi binding activity. Immunohistochemical staining of granulocytes and macrophages. A frozen section from rat spleen was stained with the Mouse Anti-Rat CD11b/c antibody. Granulocytes and macrophages can be identified by the intense brown labeling of their cell surface membranes (40x magnification).
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
Store undiluted at 4°C.
Issekutz, Issekutz: "The contribution of LFA-1 (CD11a/CD18) and MAC-1 (CD11b/CD18) to the in vivo migration of polymorphonuclear leucocytes to inflammatory reactions in the rat." in: Immunology, Vol. 76, Issue 4, pp. 655-61, (1992) (PubMed).
Tamatani, Kotani, Miyasaka: "Characterization of the rat leukocyte integrin, CD11/CD18, by the use of LFA-1 subunit-specific monoclonal antibodies." in: European journal of immunology, Vol. 21, Issue 3, pp. 627-33, (1991) (PubMed).
Robinson, White, Mason: "MRC OX-43: a monoclonal antibody which reacts with all vascular endothelium in the rat except that of brain capillaries." in: Immunology, Vol. 57, Issue 2, pp. 231-7, (1986) (PubMed).
Robinson, White, Mason: "Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42, the latter recognizing complement receptor type 3." in: Immunology, Vol. 57, Issue 2, pp. 239-47, (1986) (PubMed).