Reacts with FMS-like tyrosine kinase 3 (flt3), a 155-160 kD, class III tyrosine kinase receptor (CD135), which is structurally related to the receptors for PDGF, SCF-1 and kit ligand. CD135 is expressed on multipotential, myelomonocytic and primitive B-cell progenitors. The most primitive hematopoietic progenitor cells express low levels of CD135. CD135 plays the role of growth factor receptor for early hematopoietic progenitors. Reports from studies with knockout mice have shown that targeted CD135 disruption impaired the development of primitive progenitor cells of all hematopoietic lineages with significant impact on lymphopoietic precursors. Profile of REH cell line analyzed by flow cytometry
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