Insulin Receptor antibody
-
- Target See all Insulin Receptor (INSR) Antibodies
- Insulin Receptor (INSR)
-
Reactivity
- Human
-
Host
- Mouse
-
Clonality
- Monoclonal
-
Conjugate
- This Insulin Receptor antibody is un-conjugated
-
Application
- Flow Cytometry (FACS)
- Brand
- BD Pharmingen™
- Characteristics
-
Reacts with insulin receptor (IR), a glycoprotein composed of two extracellular α-subunits (130 kDa) and two transmembrane β-subunits (95 kDa). It is expressed on human hematopoietic and non-hematopoietic cells, but unlike the insulin-like growth factor receptor (IGF-IR), which is ubiquitous, the insulin receptor is restricted to major target tissues of insulin action. Upon binding insulin, the IR subunits form a heterotetramer of two α and two β subunits resulting in autophosphorylation and activation of the tyrosine kinase activity of the receptor. This ligand-receptor interaction is important in regulating cell metabolism and growth. 3B6/IR monoclonal antibody reacts similarly to anti-human IR α, clone 47-9, an α-subunit antibody. Profile of peripheral blood monocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.
BD Pharmingen™ Purified Mouse Anti-Human CD220 - Purified - Clone 3B6/IR - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Clone
- 3B6-IR
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product INSR Primary Antibody
-
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Concentration
- 0.5 mg/mL
- Buffer
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store undiluted at 4°C.
-
-
Identification of epitopes on the human insulin receptor reacting with rabbit polyclonal antisera and mouse monoclonal antibodies." in: The Journal of biological chemistry, Vol. 265, Issue 17, pp. 9970-7, (1990) (PubMed).
: "Monoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 14, pp. 5217-21, (1989) (PubMed).
: "Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor." in: The Biochemical journal, Vol. 235, Issue 1, pp. 199-208, (1986) (PubMed).
: "
-
Identification of epitopes on the human insulin receptor reacting with rabbit polyclonal antisera and mouse monoclonal antibodies." in: The Journal of biological chemistry, Vol. 265, Issue 17, pp. 9970-7, (1990) (PubMed).
-
- Target
- Insulin Receptor (INSR)
- Alternative Name
- CD220 (INSR Products)
- Synonyms
- CD220 antibody, HHF5 antibody, 4932439J01Rik antibody, D630014A15Rik antibody, IR antibody, IR-A antibody, IR-B antibody, 18402 antibody, CG18402 antibody, DIHR antibody, DILR antibody, DIR antibody, DIRH antibody, DIRbeta antibody, DInR antibody, DInr antibody, Dir-a antibody, Dir-b antibody, Dmel\\CG18402 antibody, INR antibody, INS antibody, Inr antibody, Inr-alpha antibody, Inr-beta antibody, InsR antibody, dINR antibody, dIR antibody, dIRH antibody, dInR antibody, dInr antibody, dInsR antibody, dinr antibody, dir antibody, er10 antibody, inr antibody, insulin/insulin-like growth factor receptor antibody, l(3)05545 antibody, l(3)93Dj antibody, l(3)er10 antibody, lnR antibody, ir-A antibody, CTK-1 antibody, ir antibody, INSR antibody, NV14476 antibody, cd220 antibody, hhf5 antibody, insulin receptor antibody, Insulin-like receptor antibody, insulin receptor L homeolog antibody, INSR antibody, Insr antibody, InR antibody, LOC100122567 antibody, LOC100451802 antibody, insr.L antibody
- Background
- Synonyms: Insulin Receptor
- Pathways
- NF-kappaB Signaling, RTK Signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity
-