IDE antibody (N-Term)
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- Target See all IDE Antibodies
- IDE (Insulin-Degrading Enzyme (IDE))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat, Dog, Horse, Cow, Rabbit, Pig, Guinea Pig, Zebrafish (Danio rerio)
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This IDE antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- LDVHIGSLSD PPNIAGLSHF CEHMLFLGTK KYPKENEYSQ FLSEHAGSSN
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%
- Characteristics
- This is a rabbit polyclonal antibody against IDE. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product IDE Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 1019 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- IDE (Insulin-Degrading Enzyme (IDE))
- Alternative Name
- IDE (IDE Products)
- Synonyms
- zgc:162603 antibody, IDE antibody, 1300012G03Rik antibody, 4833415K22Rik antibody, AA675336 antibody, AI507533 antibody, INSDEGM antibody, INSULYSIN antibody, insulin degrading enzyme antibody, insulin-degrading enzyme antibody, metallopeptidase antibody, IDE antibody, ide antibody, LOC591315 antibody, CC1G_01115 antibody, Bm1_26615 antibody, PTRG_10875 antibody, SJAG_01430 antibody, EBI_21700 antibody, VDBG_06702 antibody, LOAG_08082 antibody, PGTG_04982 antibody, Tsp_00424 antibody, Ide antibody
- Background
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This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion.
Alias Symbols: FLJ35968, INSULYSIN
Protein Interaction Partner: UBC, DCP2, SUMO1, NEDD8, PUS1, TBC1D15, PUS7, ARFIP1, GSPT2, PRMT3, STAT1, SHMT2, SHMT1, PAWR, GSPT1, CTTN, CARS, ATP6V1C1, PEX5, IFIH1, Cdk1, UCHL5, SIRT4, AR, INS, IGF2, IGF1, NR3C1, APP, ZHX2,
Protein Size: 1019 - Molecular Weight
- 118 kDa
- Gene ID
- 3416
- NCBI Accession
- NM_004969, NP_004960
- UniProt
- P14735
- Pathways
- SARS-CoV-2 Protein Interactome
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