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PIAS2 antibody (C-Term)

PIAS2 Reactivity: Human, Mouse, Dog, Cow, Rabbit, Horse WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2779873
  • Target See all PIAS2 Antibodies
    PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))
    Binding Specificity
    • 10
    • 9
    • 9
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 57
    • 24
    • 21
    • 9
    • 7
    • 7
    • 7
    • 5
    • 4
    • 1
    • 1
    • 1
    Human, Mouse, Dog, Cow, Rabbit, Horse
    Host
    • 50
    • 6
    • 2
    • 1
    Rabbit
    Clonality
    • 54
    • 5
    Polyclonal
    Conjugate
    • 43
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PIAS2 antibody is un-conjugated
    Application
    • 46
    • 22
    • 13
    • 7
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    LSLIPVDPQY CPPMFLDSLT SPLTASSTSV TTTSPHESST HVSSSSSRSE
    Predicted Reactivity
    Cow: 93%, Dog: 100%, Horse: 100%, Human: 93%, Mouse: 100%, Rabbit: 93%
    Characteristics
    This is a rabbit polyclonal antibody against Pias2. It was validated on Western Blot and immunohistochemistry.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of mouse Pias2
    Top Product
    Discover our top product PIAS2 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 490 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))
    Alternative Name
    Pias2 (PIAS2 Products)
    Synonyms
    MGC83751 antibody, piasx antibody, wu:fi05f09 antibody, PIAS2 antibody, 6330408K17Rik antibody, AI462206 antibody, ARIP3 antibody, AU018068 antibody, Dib antibody, Miz1 antibody, PIASxalpha antibody, PIASxb antibody, PIASxbeta antibody, SIZ2 antibody, DIP antibody, MIZ antibody, MIZ1 antibody, PIASX antibody, PIASX-ALPHA antibody, PIASX-BETA antibody, ZMIZ4 antibody, protein inhibitor of activated STAT 2 L homeolog antibody, protein inhibitor of activated STAT 2 antibody, protein inhibitor of activated STAT, 2 antibody, pias2.L antibody, PIAS2 antibody, pias2 antibody, Pias2 antibody
    Background
    Pias2 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. It plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It seems to be mostly involved in gene silencing. It binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity.
    Alias Symbols: 6330408K17Rik, AI462206, ARIP3, AU018068, Dib, Miz1, PIASxalpha, PIASxb, PIASxbeta, SIZ2
    Protein Interaction Partner: Pparg, Egr2, Plagl2, Trim32, Trp53, DHX9, Nfkb1, Gtf2i, GTF2IRD1, HDAC3,
    Protein Size: 490
    Molecular Weight
    54 kDa
    Gene ID
    17344
    NCBI Accession
    NM_001164167
    UniProt
    Q8C5D8
    Pathways
    JAK-STAT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
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