p300 antibody (AA 1572-2371)
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- Target See all p300 (EP300) Antibodies
- p300 (EP300) (E1A Binding Protein P300 (EP300))
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Binding Specificity
- AA 1572-2371
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Reactivity
- Human, Mouse, Rat, Monkey, Mink
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This p300 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificity
- Reacts with human p300 protein (residues 1868-1921)
- Cross-Reactivity
- Mouse (Murine)
- Cross-Reactivity (Details)
- Cross reacts with proteins from mouse, rat, monkey and mink.
- Purification
- Purified (protein A)
- Immunogen
- Fusion protein containing residues 1572-2371 of human p300
- Clone
- RW128
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product EP300 Primary Antibody
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- Application Notes
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Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
ICC/IF1:10-1:2000, IP1:10-1:500, WB1:250-1:500 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS, pH 7.4, Sodium azide 0.1 %
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C/-80 °C
- Storage Comment
- Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
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- Target
- p300 (EP300) (E1A Binding Protein P300 (EP300))
- Alternative Name
- p300 (EP300 Products)
- Synonyms
- KAT3B antibody, RSTS2 antibody, p300 antibody, A430090G16 antibody, A730011L11 antibody, p300 HAT antibody, E1A binding protein p300 antibody, histone acetyltransferase p300 antibody, EP300 antibody, LOC446056 antibody, ep300 antibody, Ep300 antibody
- Background
- Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.
- Gene ID
- 2033
- UniProt
- Q09472
- Pathways
- p53 Signaling, Notch Signaling, Interferon-gamma Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Regulation of Cell Size
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