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GRB2 antibody (N-Term)
GRB2
Reactivity: Human, Mouse, Rat
WB
Host: Mouse
Monoclonal
3F2
unconjugated
Product Details anti-GRB2 Antibody
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Target
See all GRB2 Antibodies
GRB2
(Growth Factor Receptor-Bound Protein 2 (GRB2))
Binding Specificity
All epitopes for GRB2 antibodies
N-Term
Reactivity
All reactivities for GRB2 antibodies
Human, Mouse, Rat
Host
All hosts for GRB2 antibodies
Mouse
Clonality
All clonalities for GRB2 antibodies
Monoclonal
Conjugate
All conjugates for GRB2 antibodies
This GRB2 antibody is un-conjugated
Application
All applications for GRB2 antibodies
Western Blotting (WB)
Cross-Reactivity (Details)
Species reactivity (tested):Human, Mouse, Rat
Purification
Ammonium sulfate precipitation and affinity chromatography on protein A
Immunogen
Recombinant Ash/Grb-2
Clone
3F2
Isotype
IgG1
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Reconstitution
Restore with 100 μL of distilled water.
Buffer
PBS, 1 mg/mL Sodium azide, 10 mg/mL sucrose
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted (in aliquots) at -20 °C.
Target Details for GRB2
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Target
GRB2
(Growth Factor Receptor-Bound Protein 2 (GRB2))
Alternative Name
GRB2 / ASH (GRB2 Products )
Synonyms
GRB2 antibody, grb2 antibody, AA408164 antibody, Ash antibody, ASH antibody, EGFRBP-GRB2 antibody, Grb3-3 antibody, MST084 antibody, MSTP084 antibody, NCKAP2 antibody, wu:fb18e12 antibody, wu:fb34e06 antibody, zgc:73077 antibody, growth factor receptor bound protein 2 antibody, growth factor receptor-bound protein 2 antibody, growth factor receptor-bound protein 2b antibody, GRB2 antibody, grb2 antibody, Grb2 antibody, grb2b antibody
Background
Grb2 (Growth factor receptor bound protein 2) also known as Ash, is a 25-28 kDa molecule composed of central Src homology (SH2) domain and SH3 domains. Grb2 associates with tyrosine phosphorylated proteins such as EGFR, PDGFR, IRS-1, Shc and Gab1 via its Sh2 domain. The SH3 domain of Grb2 binds to Sos, which stimulates the GTP binding activity of Ras, cause activation of MAP kinase and other signaling pathways. Grb2 is an adaptor protein, which does not have enzymatic activity itself. Grb2 express ubiquitously and has two isoforms.Synonyms: Growth factor receptor-bound protein 2
Gene ID
2885
NCBI Accession
NP_002077
UniProt
P62993
Pathways
RTK Signaling , TCR Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Regulation of Actin Filament Polymerization , Hepatitis C , Signaling Events mediated by VEGFR1 and VEGFR2 , Signaling of Hepatocyte Growth Factor Receptor , EGFR Downregulation
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