Minichromosome Maintenance Complex Component 6 (MCM6) antibody

Details for Product No. ABIN3022687, Supplier: Log in to see
Antigen
  • CG4039
  • DmMCM6
  • DmeMCM6
  • Dmel\\CG4039
  • MCM6
  • McM6
  • fs(1)K1214
  • mcm6
  • MCG40308
  • Mis5
  • P105MCM
  • Mcmd6
  • mis5
  • mmcm6
  • ASP-l1
  • D1Wsu22e
  • Minichromosome maintenance 6
  • DNA replication licensing factor MCM6
  • minichromosome maintenance complex component 6
  • minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
  • Protein MCM-6
  • Mcm6
  • TP02_0113
  • PVX_114735
  • CMU_027970
  • MCM6
  • mcm6
  • mcm-6
Alternatives
anti-Human Minichromosome Maintenance Complex Component 6 antibody for Western Blotting
Reactivity
Mouse (Murine), Rat (Rattus), Human
89
32
20
17
12
12
10
8
4
2
1
1
1
1
Host
Rabbit
80
7
4
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
83
45
29
27
17
6
5
3
2
2
1
1
1
1
1
Options
Supplier
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Immunogen Recombinant protein of human MCM6
Isotype IgG
Purification Affinity purification
Alternative Name MCM6 (MCM6 Antibody Abstract)
Background The MCM genes were firstly identified in yeast defective in minichromosome maintenance and have since been shown to have roles in the progression of the cell cycle, and most of them are cell division control genes[PMID: 18096807]. MCM2-7 complex are suggested to be DNA licensing factors which bind to the DNA after mitosis and enable DNA replication before being removed during S phase. Mini-chromosome maintenance 6 (MCM6) is one component of the MCM2-7 complex which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells[PMID: 9305914]. MCM6 single subunit forms homohexamer and contains an ATP-dependent and replication fork stimulated 3 to 5 DNA unwinding activity along with intrinsic DNA-dependent ATPase and ATP-binding activities [PMID:21336027].
Synonyms: Mis5, P105MCM, MCG40308
Gene ID 4175
UniProt Q14566
Research Area Chromatin and Nuclear Signaling, Chromatin Binding Proteins, DNA/RNA
Pathways DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
Application Notes Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze / thaw cycles
Storage -20 °C/-80 °C
Supplier Images
Immunofluorescence (IF) image for anti-Minichromosome Maintenance Complex Component 6 (MCM6) antibody (ABIN3022687) anti-Minichromosome Maintenance Complex Component 6 (MCM6) antibody
Immunohistochemistry (IHC) image for anti-Minichromosome Maintenance Complex Component 6 (MCM6) antibody (ABIN3022687) anti-Minichromosome Maintenance Complex Component 6 (MCM6) antibody (Image 2)
Western Blotting (WB) image for anti-Minichromosome Maintenance Complex Component 6 (MCM6) antibody (ABIN3022687) Western blot analysis of extracts of various cell lines, using MCM6 antibody.
Immunofluorescence (IF) image for anti-Minichromosome Maintenance Complex Component 6 (MCM6) antibody (ABIN3022687) anti-Minichromosome Maintenance Complex Component 6 (MCM6) antibody (Image 4)
Background publications Tran, Pham, Tuteja, Tuteja: "Inhibition of unwinding and ATPase activities of pea MCM6 DNA helicase by actinomycin and nogalamycin." in: Plant signaling & behavior, Vol. 6, Issue 3, pp. 327-9, 2011 (PubMed).

Groth, Corpet, Cook, Roche, Bartek, Lukas, Almouzni: "Regulation of replication fork progression through histone supply and demand." in: Science (New York, N.Y.), Vol. 318, Issue 5858, pp. 1928-31, 2007 (PubMed).

Ishimi: "A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex." in: The Journal of biological chemistry, Vol. 272, Issue 39, pp. 24508-13, 1997 (PubMed).

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