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serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) (Middle Region) antibody

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Antigen
Synonyms
ATSPT1, SERINE PALMITOYLTRANSFERASE 1, serine palmitoyltransferase 1, Afu6g00300, HSAN1, HSN1, LBC1, LCB1, SPT1, SPTI, wu:fc75h04, wu:fp41c08, zgc:112247, AW552086, C77762, E030036H05, Lcb1, RGD130661 ... show more
ATSPT1, SERINE PALMITOYLTRANSFERASE 1, serine palmitoyltransferase 1, Afu6g00300, HSAN1, HSN1, LBC1, LCB1, SPT1, SPTI, wu:fc75h04, wu:fp41c08, zgc:112247, AW552086, C77762, E030036H05, Lcb1, RGD1306617, Spt1 show less
Epitope
Middle Region
(34), (11), (7), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Chicken, Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus), Xenopus laevis, Zebrafish (Danio rerio)
(94), (32), (26), (2), (1), (1), (1), (1)
Host
Rabbit
(91), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(82), (44), (16), (10), (10), (3), (2), (2), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the middle region of human SPTLC1
Blocking Peptide Blocking peptide for this product available: ABIN984391
Sequence ICPLPELVKL KYKYKARIFL EESLSFGVLG EHGRGVTEHY GINIDDIDLI
Predicted Reactivity Guinea pig : 100 %, Human : 100 %, Mouse : 100 %, Rabbit : 100 %, Rat : 100 %, African clawed frog : 90 %, Dog : 90 %, Zebrafish : 90 %, Chicken : 80 %
Characteristics This is a rabbit polyclonal antibody against SPTLC1. It was validated on Western Blot and immunohistochemistry.
Purification Affinity Purified
Alternative Name SPTLC1 (SPTLC1 Antibody Abstract)
Background Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. SPTLC1 is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in SPTLC1 gene were identified in patients with hereditary sensory neuropathy type 1.Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified.
Molecular Weight 53 kDa
Gene ID 10558
NCBI Accession NP_006406, NM_006415
UniProt O15269
Research Area Cancer, Metabolism
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 473 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) (Middle Region) antibody (ABIN310841) anti-serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) (Middle Region) antibody
Immunohistochemistry (IHC) image for anti-serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) (Middle Region) antibody (ABIN310841) anti-serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) (Middle Region) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) (Middle Region) antibody (ABIN310841) anti-serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) (Middle Region) antibody (Image 3)
Background publications McCampbell, Truong, Broom et al.: "Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy." in: Human molecular genetics, Vol. 14, Issue 22, pp. 3507-21, 2005 (PubMed).

Catalog No. ABIN310841
$289.00
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