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TAR DNA Binding Protein (TARDBP) (AA 1-260), (N-Term) antibody

Details for Product No. ABIN317572, Supplier: Log in to see
Antigen
  • 1190002A23Rik
  • ALS10
  • C85084
  • DKFZp459I2127
  • TARDBP
  • tardbp
  • TDP-43
  • TDP43
  • Tdp43
  • wu:fb77f02
  • wu:fc52g10
Epitope
AA 1-260, N-Term
26
18
17
16
13
12
11
8
7
7
5
4
3
3
2
2
1
1
Reactivity
Human
192
74
57
11
9
8
8
7
6
4
4
2
1
Host
Mouse
112
71
15
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
8
8
7
5
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
179
107
51
41
28
18
18
11
10
5
5
3
3
2
Supplier
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Immunogen Recombinant Human TARDBP (1-260 aa) purified from E. coli.
Clone K1B8
Isotype IgG1
Specificity The antibody recognizes Human TARDBP. Other species not tested.
Characteristics Synonyms: TDP43, TDP-43, TAR DNA-binding protein 43
Purification Protein-G Affinity Chromatography
Alternative Name TARDBP (TARDBP Antibody Abstract)
Background TAR DNA binding protein (TARDBP), also known as TDP-43, is a cellular protein. TARDBP was identified as the disease accumulating protein in patients with frontotemporal lobar degeneration (FTLD) with ubiquitin inclusions (FTLD-U) and in amyotrophic lateral sclerosis (ALS). TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. In addition, this protein regulates alternate splicing of the cystic fibrosis transmembrane receptor (CFTR) gene.Synonyms: TAR DNA-binding protein 43, TDP-43, TDP43
Gene ID 23435
UniProt Q13148
Research Area Chromatin and Nuclear Signaling, Transcription Factors, DNA/RNA, Hormones, Cytokines
Application Notes ELISA. Western blot (1/1,000-1/2,000). Immunohistochemistry on Paraffin Sections (1/50-1/100).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4, 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (N-Term) antibody (ABIN317572) anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (N-Term) antibody
Immunohistochemistry (IHC) image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (N-Term) antibody (ABIN317572) anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (N-Term) antibody (Image 2)
Western Blotting (WB) image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (N-Term) antibody (ABIN317572) anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (N-Term) antibody (Image 3)
Background publications Kabashi, Valdmanis, Dion, Spiegelman, McConkey, Vande Velde, Bouchard, Lacomblez, Pochigaeva, Salachas, Pradat, Camu, Meininger, Dupre, Rouleau: "TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis." in: Nature genetics, Vol. 40, Issue 5, pp. 572-4, 2008

Rutherford, Zhang, Baker, Gass, Finch, Xu, Stewart, Kelley, Kuntz, Crook, Sreedharan, Vance, Sorenson, Lippa, Bigio, Geschwind, Knopman, Mitsumoto, Petersen, Cashman, Hutton, Shaw, Boylan, Boeve et al.: "Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis. ..." in: PLoS genetics, Vol. 4, Issue 9, pp. e1000193, 2008