PMAIP1
Reactivity: Human
ELISA
Host: Rabbit
Polyclonal
HRP
Application Notes
Western Blot: 0.5 - 1.0g/mL, detects a band of approximately 11 kDa in human stomach celllysates. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Noxa is an 11 kDa member of the BH3-only proapoptotic protein family. Noxa is localised to the mitochondria and is a transcriptional target of p73, p53 and BH3-only proteins. It is thought to induce apoptosis when activated, lowering the activity of anti-apoptotic Bcl-2-like proteins. It can be upregulated by mitogenic activation, independently of p53. In humans, along with Mcl-1 it is thought to form a selective pathway that restrains lymphocyte proliferation.Synonyms: PMA-induced protein 1, PMAIP1, Phorbol-12-myristate-13-acetate-induced protein 1