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p53 antibody (Tumor Protein P53) (pSer37)

Details for Product anti-TP53 Antibody No. ABIN319217, Supplier: Log in to see
Antigen
  • tp53
  • p53
  • TP53
  • Tp53
  • bbl
  • bfy
  • bhy
  • p44
  • TpMs
  • BCC7
  • LFS1
  • P53
  • TRP53
  • Trp53
  • Xp53
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • wu:fb40d06
  • zgc:111919
  • cellular tumor antigen p53
  • tumor protein p53
  • tumor supressor p53
  • p53 tumor suppressor
  • transformation related protein 53
  • transformation related protein 53, pseudogene
  • trichoplein, keratin filament binding
  • Wistar clone pR53P1 p53 pseudogene
  • CpipJ_CPIJ002758
  • TP53
  • tp53
  • P53
  • Trp53
  • Trp53-ps
  • TCHP
  • Tp53
  • p53-ps
Alternatives
anti-Human p53 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
pSer37
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99
84
68
64
64
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54
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41
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2
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2
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2
2
2
2
2
2
2
2
2
2
1
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1
1
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1
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1
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Reactivity
Human
2131
480
395
169
127
94
68
64
34
23
18
17
16
16
15
11
6
4
4
4
4
3
3
2
2
1
Host
Rabbit
1252
969
7
3
3
1
1
Clonality
Polyclonal
Conjugate
This p53 antibody is un-conjugated
71
68
56
47
36
35
24
24
21
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7
4
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1
Application
Immunofluorescence (IF), Western Blotting (WB)
1719
716
636
580
526
466
400
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251
179
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41
32
31
18
17
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13
9
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4
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2
2
1
1
1
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1
Options
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human p53 around the phosphorylation site of Serine 37 (L-P-SP-Q-A).
Specificity The antibody detects endogenous levels of p53 only when phosphorylated at Serine 37.
Purification Affinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name p53 (TP53) (TP53 Antibody Abstract)
Background Synonyms: Cellular tumor antigen p53, NY-CO-13, Phosphoprotein p53, Tumor suppressor p53
Gene ID 7157
NCBI Accession NP_000537
UniProt P04637
Pathways p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus
Application Notes Western Blot: 1/500-1/1000. Immunofluorescence: 1/100-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at-20 °C.
Supplier Images
 image for anti-p53 antibody (Tumor Protein P53) (pSer37) (ABIN319217) anti-Tumor Protein P53 (TP53) (pSer37) antibody
 image for anti-p53 antibody (Tumor Protein P53) (pSer37) (ABIN319217) anti-Tumor Protein P53 (TP53) (pSer37) antibody (Image 2)
Background publications Solomon, Pasupuleti, Xu, McDonagh, Curtis, DiStefano, Huber: "Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage." in: Molecular and cellular biology, Vol. 26, Issue 1, pp. 28-38, 2005 (PubMed).

Cases, de Lorenzo: "The black cat/white cat principle of signal integration in bacterial promoters." in: The EMBO journal, Vol. 20, Issue 1-2, pp. 1-11, 2001 (PubMed).

Duboule: "Hox is in the hair: a break in colinearity?" in: Genes & development, Vol. 12, Issue 1, pp. 1-4, 1998 (PubMed).