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KIT antibody (pTyr936)
KIT
Reactivity: Human
IHC (p)
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-KIT Antibody
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Target
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KIT
(Mast/stem Cell Growth Factor Receptor (KIT))
Binding Specificity
All epitopes for KIT antibodies
pTyr936
Reactivity
All reactivities for KIT antibodies
Human
Host
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Rabbit
Clonality
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Polyclonal
Conjugate
All conjugates for KIT antibodies
This KIT antibody is un-conjugated
Application
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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificity
C-kit (phospho-Tyr936) Antibody AP08039PU detects endogenous levels of c-kit only when phosphorylated at Tyrosine 936.
Purification
Immunoaffinity Chromatography.
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human c- kit around the phosphorylation site of Tyrosine 936 (H-I-YP-S-N).
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Alternatives
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Application Details
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Application Notes
Immunohistochemistry (1/50-1/100). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Buffer
PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
Store the antibody (in aliquots) at-20 °C.
Target Details for KIT
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Target
KIT
(Mast/stem Cell Growth Factor Receptor (KIT))
Alternative Name
CD117 / C-Kit (KIT Products )
Synonyms
C-Kit antibody, CD117 antibody, PBT antibody, SCFR antibody, Bs antibody, Fdc antibody, Gsfsco1 antibody, Gsfsco5 antibody, Gsfsow3 antibody, SCO1 antibody, SCO5 antibody, SOW3 antibody, Ssm antibody, Tr-kit antibody, W antibody, c-KIT antibody, c-kit antibody, MGF antibody, KIT antibody, C-KIT antibody, kit antibody, receptor antibody, sparse antibody, Xkl-1 antibody, kit-a antibody, kit-b antibody, kl1-A antibody, krk1 antibody, pbt antibody, scfr antibody, KIT proto-oncogene receptor tyrosine kinase antibody, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a antibody, KIT proto-oncogene receptor tyrosine kinase S homeolog antibody, KIT antibody, Kit antibody, kita antibody, kit antibody, kit.S antibody
Background
C-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.Synonyms: KIT, Mast/stem cell growth factor receptor, Proto-Oncogene Tyrosine-Protein Kinase, SCFR
Gene ID
3815
NCBI Accession
NP_000213
UniProt
P10721
Pathways
RTK Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Sensory Perception of Sound , Stem Cell Maintenance , Production of Molecular Mediator of Immune Response , Regulation of long-term Neuronal Synaptic Plasticity
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