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Insulin-Degrading Enzyme (IDE) (Internal Region) antibody

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Synonyms zgc:162603, IDE, 1300012G03Rik, 4833415K22Rik, AA675336, AI507533, INSDEGM, INSULYSIN
Internal Region
(33), (13), (13), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
(102), (43), (34), (6), (3), (3), (2), (2), (2), (1)
(70), (40), (8)
(6), (5), (5), (4), (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Methode Type Peptide ELISA
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
(93), (48), (35), (23), (13), (3), (3), (2), (2), (1), (1)
Pubmed 1 reference available
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Quantity 100 μg
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Immunogen Peptide with sequence C-QQYNFDRDNTE, from the internal region of the protein sequence according to NP_004960.1, NP_001159418.1.
Blocking Peptide Blocking peptide for this product available: ABIN369685
Specificity This antibody is expected to recognize both reported isoforms (NP_004960.1 and NP_001159418.1).
Cross-Reactivity Dog (Canine)
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Alternative Name Insulysin / Insulinase (IDE Antibody Abstract)
Background Synonyms: insulinase, insulysin, insulin-degrading enzyme, FLJ35968, INSULYSIN, IDE
Gene ID 3416
NCBI Accession NP_004960, NP_001159418
Application Notes ELISA: antibody detection limit dilution 1:32000.
Western blot: Approx 110-120 kDa band observed in lysates of cell line K562 (calculated MW of 118 kDa according to NP_004960.1). In transfected HEK293 transiently expressing Insulysin a band of approx. 110 kDa is observed. This band is not observed in the non-transfected HEK293. Recommended concentration: 0.1-0.3 µg/mL.
IHC: In paraffin embedded Human Lung shows cytoplasm staining of alveolar macrophages. Recommended concentration: 3-6 µg/mL.
Restrictions For Research Use only
Format Liquid
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Supplier Images
 image for anti-Insulin-Degrading Enzyme (IDE) (Internal Region) antibody (ABIN334425) ABIN334425 (0.1µg/ml) staining of K562 cell lysate (35µg protein in RIPA buffer). Pri...
Background publications Zhao, Xiang, Haroutunian et al.: "Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease." in: Neurobiology of aging, Vol. 28, Issue 6, pp. 824-30, 2007 (PubMed).

Catalog No. ABIN334425
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