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Details for Product No. ABIN350454

Brain-Derived Neurotrophic Factor (BDNF) (N-Term) antibody

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Antigen
Synonyms ANON2, BULN2, bdnf-A, BDNF, bdnf, Bdnf
Epitope
»Alternatives N-Term
Reactivity
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 7 references available
Catalog no. ABIN350454
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from human mature BDNF (BDNF, Brain-derived neurotrophic factor, Abrineurin) conjugated to an immunogenic carrier protein was used as the immunogen. The peptide is homologous in many other species including rat, mouse, zebra fish and xenopus.
Isotype IgG
Specificity Appears to be specific for mature BDNF.
Purity IgG
Alternative Name mature BDNF (Brain derived neurotrophic factor)
Background Function: Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Subunit: Monomers and homodimers. Binds to NTRK2/TRKB.
Subcellular location: Secreted. Also known as: Brain-derived neurotrophic factor, BDNF, Abrineurin.
UniProt P23560
Application Notes IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Ohara, Gahara, Teraoka et al.: "A rat brain-derived neurotrophic factor-encoding gene generates multiple transcripts through alternative use of 5' exons and polyadenylation sites." in: Gene, Vol. 121, Issue 2, pp. 383-6, 1992 (PubMed).

Maisonpierre, Le Beau, Espinosa et al.: "Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations." in: Genomics, Vol. 10, Issue 3, pp. 558-68, 1991 (PubMed).

Yancopoulos, Maisonpierre, Ip et al.: "Neurotrophic factors, their receptors, and the signal transduction pathways they activate." in: Cold Spring Harbor symposia on quantitative biology, Vol. 55, pp. 371-9, 1992 (PubMed).

Hallboeoek, Ibuaunez, Persson: "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary." in: Neuron, Vol. 6, Issue 5, pp. 845-58, 1991 (PubMed).

Timmusk, Palm, Metsis et al.: "Multiple promoters direct tissue-specific expression of the rat BDNF gene." in: Neuron, Vol. 10, Issue 3, pp. 475-89, 1993 (PubMed).

Liu, Lu, Zhu et al.: "Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine." in: Brain research, Vol. 1067, Issue 1, pp. 1-12, 2006 (PubMed).

Aid, Kazantseva, Piirsoo et al.: "Mouse and rat BDNF gene structure and expression revisited." in: Journal of neuroscience research, Vol. 85, Issue 3, pp. 525-35, 2007 (PubMed).

Alternatives for antigen "Brain-Derived Neurotrophic Factor (BDNF)", type "Antibodies"
Hosts (117), (29), (14), (8), (5)
Reactivities (149), (49), (48), (27), (25), (25), (24), (4), (1)
Applications (130), (81), (46), (25), (20), (19), (10), (10), (8), (6), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (1)
Conjugates (13), (5), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Epitopes (9), (7), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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