Proliferating Cell Nuclear Antigen (PCNA) (C-Term) antibody

Details for Product No. ABIN350772
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Antigen
Synonyms
PCNAR, Pcna/cyclin, 53/13, CG9193, DmPCNA, Dmel\\CG9193, MUS209, Mus209, PCNA, PCNA/mus209, Pcna, dPCNA, l(2)02448, l(2)56F, l(2)56Fa, l(2)s1534, pcna, cb16, fb36g03, wu:fa28e03, wu:fb36g03, AO0900030 ... show more
PCNAR, Pcna/cyclin, 53/13, CG9193, DmPCNA, Dmel\\CG9193, MUS209, Mus209, PCNA, PCNA/mus209, Pcna, dPCNA, l(2)02448, l(2)56F, l(2)56Fa, l(2)s1534, pcna, cb16, fb36g03, wu:fa28e03, wu:fb36g03, AO090003000846 show less
Epitope
C-Term
(21), (14), (13), (6), (5), (5), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus), Mouse (Murine)
(308), (183), (146), (78), (68), (65), (15), (13), (13), (12), (9), (9), (8), (6), (4), (4), (4), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(176), (174), (5), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(21), (18), (6), (6), (6), (6), (6), (6), (6), (6), (6), (4), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(243), (121), (85), (73), (60), (59), (57), (36), (31), (30), (2), (2), (1), (1), (1), (1), (1)
Pubmed 4 references available
Catalog no. ABIN350772
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the c-terminal region of rat Proliferating cell nuclear antigen (PCNA) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in human and rat.
Specificity Specific for RCAN1.
Purification IgG
Alternative Name Prolifeing cell nuclear antigen (PCNA)
Background Function: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involvement in disease: Antibodies are present in sera from patients with systemic lupus erythematosus. Also known as: Cyclin, DNA polymerase delta auxiliary protein, Polymerase delta accessory protein, Proliferating Cell Nuclear Antigen.
UniProt Q9JHG6
Application Notes A concentration of 10-50 µg/mL is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
General Almendral, Huebsch, Blundell et al.: "Cloning and sequence of the human nuclear protein cyclin: homology with DNA-binding proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, Issue 6, pp. 1575-9, 1987 (PubMed).

Deloukas, Matthews, Ashurst et al.: "The DNA sequence and comparative analysis of human chromosome 20." in: Nature, Vol. 414, Issue 6866, pp. 865-71, 2002 (PubMed).

Sakurai, Kitano, Yamaguchi et al.: "Structural basis for recruitment of human flap endonuclease 1 to PCNA." in: The EMBO journal, Vol. 24, Issue 4, pp. 683-93, 2005 (PubMed).

Unk, Hajdú, Fátyol et al.: "Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 48, pp. 18107-12, 2006 (PubMed).

Hosts (176), (174), (5), (2)
Reactivities (308), (183), (146), (78), (68), (65), (15), (13), (13), (12), (9), (9), (8), (6), (4), (4), (4), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Applications (243), (121), (85), (73), (60), (59), (57), (36), (31), (30), (2), (2), (1), (1), (1), (1), (1)
Conjugates (21), (18), (6), (6), (6), (6), (6), (6), (6), (6), (6), (4), (1), (1), (1), (1)
Epitopes (21), (14), (13), (6), (5), (5), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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