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Details for Product No. ABIN351227

Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (3rd Extracellular Loop) antibody

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Antigen
Synonyms LTRPC6, TRPP8, CMR1, LTrpC-6, Trp-p8, TRPM8, trpp8, ltrpc6, trpm8b
Epitope
»Alternatives 3rd Extracellular Loop
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN351227
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the 3d extracellular loop of human TRPM8 (LTRPC6, TRPP8, LTrpC6) conjugated to an immunogenic carrie protein was used as the immunogen.
Isotype IgG
Specificity Appears to be specific for TRPM8.
Purity IgG
Alternative Name TRPM8 (LTRPC6,TRPP8, LtrpC6)
Background Function: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in prostate. Also expressed in most in prostate tumors. Also expressed in non-prostatic primary tumors such as colon, lung, breast and skin tumors.
Miscellaneous: The sensation of coolness triggered by eucalyptol or menthol may be explained by the fact that menthol and cool temperatures sensations are detected by this protein.
Miscellaneous: Its expression in most prostate tumors as well as the presence of an immunogenic epitope suggest that it may be suitable for the design of peptide vaccination strategies for prostate cancers. Also known as: Transient receptor potential cation channel subfamily M member 8, transient receptor potential-p8, Trp-p8, long transient receptor potential channel 6, LTrpC6, TRPP8, LTRPC6, MGC2849.
UniProt Q7Z2W7
Application Notes IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Tsavaler, Shapero, Morkowski et al.: "Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins." in: Cancer research, Vol. 61, Issue 9, pp. 3760-9, 2001 (PubMed).

Kiessling, Füssel, Schmitz et al.: "Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein trp-p8." in: The Prostate, Vol. 56, Issue 4, pp. 270-9, 2003 (PubMed).

Voets, Droogmans, Wissenbach et al.: "The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels." in: Nature, Vol. 430, Issue 7001, pp. 748-54, 2004 (PubMed).

Alternatives for antigen "Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8)", type "Antibodies"
Hosts (89), (4), (3)
Reactivities (75), (29), (27), (13), (2), (2), (1), (1), (1), (1)
Applications (68), (31), (30), (28), (10), (5), (3), (3), (2), (1), (1)
Conjugates (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (10), (9), (6), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
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