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MEK1 antibody (pSer222)
MAP2K1
Reactivity: Human
EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-MEK1 Antibody
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Target
See all MEK1 (MAP2K1) Antibodies
MEK1 (MAP2K1)
(Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))
Binding Specificity
All epitopes for MEK1 antibodies
pSer222
Reactivity
All reactivities for MEK1 antibodies
Human
Host
All hosts for MEK1 antibodies
Rabbit
Clonality
All clonalities for MEK1 antibodies
Polyclonal
Conjugate
All conjugates for MEK1 antibodies
This MEK1 antibody is un-conjugated
Application
All applications for MEK1 antibodies
Enzyme Immunoassay (EIA)
Specificity
This antibody reacts to MEK1 pSer222.
Purification
Protein A column, followed by two-step phosphospecific peptide affinity purification
Immunogen
This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S222 of human MEK1.
Isotype
Ig Fraction
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Discover our top product MAP2K1 Primary Antibody
Alternatives
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Application Details
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Application Notes
ELISA: 1/1,000. Dot Blot: 1/500. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
0.25 mg/mL
Buffer
PBS with 0.09 % (W/V) sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Target Details for MEK1
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Target
MEK1 (MAP2K1)
(Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))
Alternative Name
MAP2K1 (MAP2K1 Products )
Synonyms
Mek1 antibody, CFC3 antibody, MAPKK1 antibody, MEK1 antibody, MKK1 antibody, PRKMK1 antibody, MEKK1 antibody, Prkmk1 antibody, mek-2 antibody, si:ch211-242m18.2 antibody, wu:fj56a12 antibody, wu:fj61b01 antibody, zgc:56557 antibody, ATMEK1 antibody, F20B18.180 antibody, F20B18_180 antibody, MAP kinase/ ERK kinase 1 antibody, MITOGEN ACTIVATED PROTEIN KINASE KINASE antibody, MITOGEN ACTIVATED PROTEIN KINASE KINASE 1 antibody, NMAPKK antibody, MEK antibody, mitogen activated protein kinase kinase 1 antibody, mitogen-activated protein kinase kinase 1 antibody, mitogen-activated protein kinase kinase 1 L homeolog antibody, MAP kinase/ ERK kinase 1 antibody, Map2k1 antibody, MAP2K1 antibody, map2k1.L antibody, map2k1 antibody, MEK1 antibody
Background
MEK1is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.Synonyms: Dual specificity mitogen-activated protein kinase kinase 1, ERK activator kinase 1, MAP kinase kinase 1, MAPK/ERK kinase 1, MAPKK 1, MEK1, PRKMK1
Gene ID
5604, 9606
UniProt
Q02750
Pathways
MAPK Signaling , RTK Signaling , Interferon-gamma Pathway , Fc-epsilon Receptor Signaling Pathway , Neurotrophin Signaling Pathway , Activation of Innate immune Response , Toll-Like Receptors Cascades , Autophagy , Signaling of Hepatocyte Growth Factor Receptor , BCR Signaling
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