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NFKB1 antibody (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1) (AA 891-895)

Details for Product anti-NFKB1 Antibody No. ABIN362516, Supplier: Log in to see
Antigen
  • ebp-1
  • kbf1
  • nf-kappa-b
  • nf-kappaB
  • nfkb-p105
  • nfkb-p50
  • NF-KB1
  • NF-kappaB
  • NF-kappaB1
  • p105
  • p50
  • p50/p105
  • EBP-1
  • KBF1
  • NF-kB1
  • NF-kappa-B
  • NFKB-p105
  • NFKB-p50
  • NFkappaB
  • BICDR-1
  • bicdr1
  • ccdc64
  • NF-kB
Alternatives
anti-Human NFKB1 antibody for Western Blotting
Epitope
AA 891-895
44
42
41
39
37
35
29
13
13
13
11
10
8
8
7
7
5
4
4
4
4
4
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
495
156
137
17
17
14
12
1
1
Host
Rabbit
474
45
4
2
Clonality
Polyclonal
Conjugate
This NFKB1 antibody is un-conjugated
17
15
12
8
6
6
6
6
6
6
6
6
4
4
4
Application
Immunohistochemistry (IHC), Western Blotting (WB)
391
210
164
100
86
70
43
19
14
9
9
7
4
4
4
1
1
1
Supplier
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Immunogen Peptide sequence around AA 891-895 (A-S-S-P-V) derived from Human NFkB-p105. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Isotype IgG
Specificity The antibody detects endogenous level of total NFkB-p105 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative Name NFkappaB-p105/p50 (NFKB1 Antibody Abstract)
Background NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.
Molecular Weight 120 kDa
NCBI Accession NP_001158
UniProt P19838
Pathways NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Hou, Guan, Ricciardi: "Phosphorylation of serine 337 of NF-kappaB p50 is critical for DNA binding." in: The Journal of biological chemistry, Vol. 278, Issue 46, pp. 45994-8, 2003 (PubMed).

Baeuerle, Baltimore: "NF-kappa B: ten years after." in: Cell, Vol. 87, Issue 1, pp. 13-20, 1996 (PubMed).

Baeuerle, Henkel: "Function and activation of NF-kappa B in the immune system." in: Annual review of immunology, Vol. 12, pp. 141-79, 1994 (PubMed).

Haskill, Beg, Tompkins et al.: "Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity." in: Cell, Vol. 65, Issue 7, pp. 1281-9, 1991 (PubMed).

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