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STAT5A antibody (Signal Transducer and Activator of Transcription 5A) (AA 778-782)

Details for Product anti-STAT5A Antibody No. ABIN362573, Supplier: Login to see
Antigen
Alternatives
anti-Human STAT5A antibody for Immunohistochemistry (Frozen Sections)
Epitope
AA 778-782
94
58
43
19
16
13
9
6
6
6
5
5
5
5
4
4
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
422
203
161
28
21
17
13
11
6
1
1
Host
Rabbit
340
99
10
Clonality
Polyclonal
Conjugate
This STAT5A antibody is un-conjugated
12
11
10
8
6
5
5
4
4
3
3
2
2
2
2
2
1
1
1
1
1
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1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
341
200
135
63
57
56
38
25
18
18
17
9
6
6
5
2
2
1
1
1
1
1
Supplier
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Immunogen Peptide sequence around AA 778-782 (R-L-S-P-P) derived from Human STAT5A. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Isotype IgG
Specificity The antibody detects endogenous level of total STAT5A protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative Name STAT5A (STAT5A Antibody Abstract)
Background Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.
Molecular Weight 90 kDa
NCBI Accession NP_003143
UniProt P42229
Research Area Chromatin and Nuclear Signaling, Transcription Factors, Signaling, Receptors, Inflammation
Pathways JAK-STAT Signaling, RTK Signaling
Application Notes Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Product cited in: Cheng, Wang, Xia et al.: "A guanidine-rich regulatory oligodeoxynucleotide improves type-2 diabetes in obese mice by blocking T-cell differentiation." in: EMBO molecular medicine, Vol. 4, Issue 10, pp. 1112-25, 2012 (PubMed).

Background publications Dentelli, Del Sorbo, Rosso et al.: "Human IL-3 stimulates endothelial cell motility and promotes in vivo new vessel formation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 4, pp. 2151-9, 1999 (PubMed).

Meinke, Barahmand-Pour, Wöhrl et al.: "Activation of different Stat5 isoforms contributes to cell-type-restricted signaling in response to interferons." in: Molecular and cellular biology, Vol. 16, Issue 12, pp. 6937-44, 1997 (PubMed).

Gouilleux, Wakao, Mundt et al.: "Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription." in: The EMBO journal, Vol. 13, Issue 18, pp. 4361-9, 1994 (PubMed).