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STAT2 antibody (Signal Transducer and Activator of Transcription 2, 113kDa) (AA 688-692)

Details for Product anti-STAT2 Antibody No. ABIN363103, Supplier: Log in to see
Antigen
Alternatives
anti-Human STAT2 antibody for Western Blotting
Epitope
AA 688-692
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42
22
17
15
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13
13
11
9
8
5
5
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3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
218
80
58
3
3
3
3
3
3
3
3
Host
Rabbit
229
25
1
Clonality
Polyclonal
Conjugate
This STAT2 antibody is un-conjugated
10
9
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6
6
3
2
2
2
2
2
2
2
2
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
203
92
90
29
24
22
7
4
4
3
3
3
1
1
1
1
Supplier
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Immunogen Peptide sequence around AA 688-692 (R-K-Y-L-K) derived from Human STAT2. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Isotype IgG
Specificity The antibody detects endogenous level of total STAT2 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen. Specificity/Sensitivity Stat2 (Ab-690) Antibody detects endogenous levels of total Stat2 protein.
Alternative Name Stat2 (STAT2 Antibody Abstract)
Background STAT2 encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-a response by adenovirus.
Molecular Weight 113 kDa
NCBI Accession NP_005410
UniProt P52630
Research Area Chromatin and Nuclear Signaling, Transcription Factors, Signaling, Receptors, Inflammation
Pathways JAK-STAT Signaling
Application Notes Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Schamel, Reth: "Monomeric and oligomeric complexes of the B cell antigen receptor." in: Immunity, Vol. 13, Issue 1, pp. 5-14, 2000 (PubMed).

Horvath, Stark, Kerr et al.: "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex." in: Molecular and cellular biology, Vol. 16, Issue 12, pp. 6957-64, 1997 (PubMed).

Improta, Schindler, Horvath et al.: "Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 11, pp. 4776-80, 1994 (PubMed).

Fu, Schindler, Improta et al.: "The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 16, pp. 7840-3, 1992 (PubMed).