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KIT antibody (Mast/stem Cell Growth Factor Receptor) (AA 934-938)

Details for Product anti-KIT Antibody No. ABIN363108, Supplier: Log in to see
Antigen
  • Bs
  • CD117
  • Fdc
  • Gsfsco1
  • Gsfsco5
  • Gsfsow3
  • SCO1
  • SCO5
  • SOW3
  • Ssm
  • Tr-kit
  • W
  • c-KIT
  • C-Kit
  • PBT
  • SCFR
  • MGF
  • c-kit
  • kit oncogene
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • Kit
  • KIT
Alternatives
anti-Human KIT antibody for Immunofluorescence
Epitope
AA 934-938
77
65
41
36
32
25
23
23
19
14
14
13
13
13
13
13
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12
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3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
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1
Reactivity
Human
896
423
130
21
20
18
17
6
2
1
Host
Rabbit
646
301
234
8
1
1
Clonality
Polyclonal
Conjugate
This KIT antibody is un-conjugated
112
88
88
65
49
39
20
16
15
11
10
10
9
9
8
8
8
8
6
5
5
5
5
5
5
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4
3
3
3
3
2
2
2
2
2
2
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2
1
Application
Immunohistochemistry (IHC)
446
375
362
192
178
147
96
89
75
50
34
13
11
10
8
5
5
4
4
4
3
2
2
2
2
2
2
Options
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Immunogen Peptide sequence around AA 934-938 (H-I-Y-S-N) derived from Human c-Kit. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Isotype IgG
Specificity The antibody detects endogenous level of total c-Kit protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
Alternative Name c-kit (KIT Antibody Abstract)
Background This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K)
Molecular Weight 145 kDa
NCBI Accession NP_000213
UniProt P10721
Research Area Proliferation Markers
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Blume-Jensen, Jiang, Hyman, Lee, OGorman, Hunter: "Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility." in: Nature genetics, Vol. 24, Issue 2, pp. 157-62, 2000 (PubMed).

Lowe: "Colipase stabilizes the lid domain of pancreatic triglyceride lipase." in: The Journal of biological chemistry, Vol. 272, Issue 1, pp. 9-12, 1997 (PubMed).

Martin, Suggs, Langley, Lu, Ting, Okino, Morris, McNiece, Jacobsen, Mendiaz: "Primary structure and functional expression of rat and human stem cell factor DNAs." in: Cell, Vol. 63, Issue 1, pp. 203-11, 1990 (PubMed).

Nocka, Tan, Chiu, Chu, Ray, Traktman, Besmer: "Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W." in: The EMBO journal, Vol. 9, Issue 6, pp. 1805-13, 1990 (PubMed).