Mitogen-Activated Protein Kinase 3 (MAPK3) (pThr202), (Tyr204) antibody

Details for Product No. ABIN372623
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Antigen
Synonyms
Erk-1, Erk1, Ert2, Esrk1, Mnk1, Mtap2k, Prkm3, p44, p44erk1, p44mapk, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK, MAPK1, MNK1, zERK1, fi06b09, wu:fi06b09, Tb08. ... show more
Erk-1, Erk1, Ert2, Esrk1, Mnk1, Mtap2k, Prkm3, p44, p44erk1, p44mapk, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK, MAPK1, MNK1, zERK1, fi06b09, wu:fi06b09, Tb08.10J17.940 show less
Epitope
pThr202, Tyr204
(38), (37), (29), (17), (15), (13), (12), (12), (7), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Dog (Canine), Chicken, Human, Mouse (Murine), Rat (Rattus), Xenopus laevis, Zebrafish (Danio rerio)
(253), (142), (139), (40), (39), (36), (36), (13), (9), (6), (4), (2), (2), (1), (1)
Host
Rabbit
(212), (66), (8), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (6), (5), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(210), (90), (61), (59), (48), (43), (30), (23), (9), (4), (4), (3), (1), (1), (1), (1), (1)
Pubmed 4 references available
Catalog no. ABIN372623
Quantity 0.1 mL
Price
390.50 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr202 and Tyr204 of rat ERK/MAPK.
Isotype IgG
Specificity Recognizes the ~42k-44k ERK/MAPK phosphorylated at Thr202 and Tyr204. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide. The immunolabeling is completely eliminated by lambda-phosphatase.
Purification Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
Alternative Name MAPK3 / ERK1
Background Extracellular-Signal Regulated Kinase/Mitogen-Activated Protein Kinase (ERK/MAPK) is an integral component of cellular signaling during mitogenesis and differentiation of mitotic cells and also is thought to play a key role in learning and memory (Adams and Sweatt, 2002, Ahn, 1993, Tanoue and Nishida, 2003, Johnson and Lapadat, 2002). The activity of this kinase is regulated by dual phosphorylation at Thr202 and Tyr204 (Ahn, 1993).
Alternate names: ERK-1, ERT2, Extracellular signal-regulated kinase 1, Insulin-stimulated MAP2 kinase, MAP kinase 3, MAP kinase isoform p44, MAPK 3, Microtubule-associated protein 2 kinase, Mitogen-activated protein kinase 1, Mitogen-activated protein kinase 3, PRKM3, p44-ERK1, p44-MAPK
Gene ID 5595
NCBI Accession NP_002737
UniProt P27361
Application Notes Western Blot: 1/1000. Immunohistochemistry: 1/500. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% Glycerol.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody undiluted (in aliquots) at-20°C.
Expiry Date 12 months
Supplier Images
anti-Mitogen-Activated Protein Kinase 3 (MAPK3) (pThr202), (Tyr204) antibody anti-Mitogen-Activated Protein Kinase 3 (MAPK3) (pThr202), (Tyr204) antibody
Background publications Ahn: "The MAP kinase cascade. Discovery of a new signal transduction pathway." in: Molecular and cellular biochemistry, Vol. 127-128, pp. 201-9, 1994 (PubMed).

Adams, Sweatt: "Molecular psychology: roles for the ERK MAP kinase cascade in memory." in: Annual review of pharmacology and toxicology, Vol. 42, pp. 135-63, 2002 (PubMed).

Johnson, Lapadat: "Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases." in: Science (New York, N.Y.), Vol. 298, Issue 5600, pp. 1911-2, 2002 (PubMed).

Tanoue, Nishida: "Molecular recognitions in the MAP kinase cascades." in: Cellular signalling, Vol. 15, Issue 5, pp. 455-62, 2003 (PubMed).

Hosts (212), (66), (8), (1)
Reactivities (253), (142), (139), (40), (39), (36), (36), (13), (9), (6), (4), (2), (2), (1), (1)
Applications (210), (90), (61), (59), (48), (43), (30), (23), (9), (4), (4), (3), (1), (1), (1), (1), (1)
Conjugates (7), (6), (5), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1)
Epitopes (38), (37), (29), (17), (15), (13), (12), (12), (7), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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