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Aurora A antibody (Aurora Kinase A) (C-Term)

Details for Product anti-AURKA Antibody No. ABIN374071, Supplier: Log in to see
Antigen
  • 87A7-9/2
  • Aur-A
  • AurA
  • CG3068
  • Dmel\\CG3068
  • aur-A
  • aurA
  • ck10
  • ck[10]
  • l(3)87Ac
  • l(3)ck10
  • Aurora-A
  • Eg2
  • aik
  • ark1
  • aur-a
  • aura
  • aurora2
  • btak
  • pEg2
  • stk15
  • stk6
  • stk7
  • wu:fb37c10
  • wu:fc02c02
  • zgc:100912
  • AURKA
  • aurka
  • AIK
  • ARK1
  • AURA
  • AURORA2
  • BTAK
  • PPP1R47
  • STK15
  • STK6
  • STK7
  • AIRK1
  • AU019385
  • AW539821
  • Ark1
  • Ayk1
  • IAK
  • IAK1
  • Stk6
  • ARK-1
  • aurka-a
Alternatives
anti-Human Aurora A antibody for Immunofluorescence
Epitope
C-Term
46
41
29
15
5
4
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
217
75
49
14
8
8
3
2
1
1
1
1
Host
Goat
169
56
18
Clonality
Polyclonal
Conjugate
This Aurora A antibody is un-conjugated
11
6
6
5
5
5
2
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
185
86
76
50
34
28
16
15
12
5
4
2
1
1
Supplier
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Immunogen Peptide from the C Terminus of the protein sequence according to NP_003591.2.
Sequence C-QNKESASKQS
Specificity This antibody detects Aurora kinase A / AURKA at C-term.
Purification Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
Alternative Name Aurora Kinase A (AURKA Antibody Abstract)
Background Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment.Synonyms: AIK1, ARK1, AURA, AURKA, AURORA2, Aurora/IPL1-related kinase 1, BTAK, Breast tumor-amplified kinase, STK15, STK6, Serine/threonine kinase 15, Serine/threonine-protein kinase 6
Gene ID 6790
NCBI Accession NP_003591
UniProt O14965
Pathways Cell Division Cycle
Application Notes Peptide ELISA: Detection limit dilution 1: 128000. Western blot: 0.1-0.3 μg/mL. Approx 45 kDa band observed in lysates of cell line HeLa andJurkat lysate (calculated MW of 45.5 kDa according to NP_003591.2). In transfected HEK293transiently expressing AURKA a band of approx.45 kDa is observed. This band is notobserved in the non-transfected HEK293.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-Aurora A antibody (Aurora Kinase A) (C-Term) (ABIN374071) anti-Aurora Kinase A (AURKA) (C-Term) antibody
 image for anti-Aurora A antibody (Aurora Kinase A) (C-Term) (ABIN374071) anti-Aurora Kinase A (AURKA) (C-Term) antibody (Image 2)
Background publications Zhou, Kuang, Zhong et al.: "Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation." in: Nature genetics, Vol. 20, Issue 2, pp. 189-93, 1998 (PubMed).